Improvement of cyanobacterial-killing biologically derived substances (BDSs) using an ecologically safe and cost-effective naphthoquinone derivative
Improvement of cyanobacterial-killing biologically derived substances (BDSs) using an ecologically safe and cost-effective naphthoquinone derivative
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DOI：
10.1016/j.ecoenv.2017.02.006
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发表时间：
2017-07-01
影响因子：
6.8
通讯作者：
Han, Myung-Soo
中科院分区：
文献类型：
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作者：
Joo, Jae-Hyoung;Wang, Pengbin;Han, Myung-Soo
在以往的研究中，萘醌（NQ）化合物已被证明是有效的，选择性和生态安全的杀藻剂用于控制有害藻华物种（HABs）或冬季水华物种，如Stephanodiscus hantzschii，但是，还没有报道用于蓝藻水华物种的基于NQ的杀藻剂。在这项研究中，我们开发了31 NQ化合物，以研究用于减轻蓝藻水华的杀藻剂。此外，为了更好地将这些化合物应用于该领域，我们减少了生产步骤的数量，以开发具有成本效益的杀藻剂。在初步试验中，我们筛选出对目标蓝藻显示出最佳杀藻活性的NQ化合物，所述目标蓝藻包括细丝藻属、长孢藻属、微囊藻属、颤藻属和念珠藻属。化合物NQ 2-0在低浓度（>= 1 μ M）下对目标藻类显示出最高的杀藻活性（90%）。观察到1 μ M NQ 2-0对非目标藻类，如硅藻（Stephanodiscus hantzschii、Cyclotella meneghiniana、Synedra acus和Aulacoseira granulata）或绿色藻类（Cosmarium biocuiatum和Scenedesmus quadricauda）的杀藻效果非常有限，且效果不超过15-25%（对S. quadricauda）。NQ 2-0（1 μ M）没有表现出生态毒性，表现为Pseudokirchneriella subcapitata（100%）、大型蚤（100%）和斑马鱼（100%）的存活率。此外，慢性生态毒性评估显示，对D的生存，生长或繁殖没有毒性。magna.此外，NQ 2-0从现场水样中迅速消散，半衰期约为3.2天。这些结果表明，NQ 2-0可能是一种选择性和生态安全的杀藻剂，以减轻有害的蓝藻水华。
In previous studies, naphthoquinone (NQ) compounds have been shown to be effective, selective, and ecologically safe algicides for controlling harmful algal blooming species (HABs) or winter bloom species, such as Stephanodiscus hantzschii However, there are no reports on NQ-based algicides for use with cyanobacterial blooming species. In this study, we developed 31 NQ compounds to investigate algicides for mitigating cyanobacterial blooms. In addition, to better apply these compounds in the field, we reduced the number of production steps to develop a cost-effective algicide. In preliminary testing, we screened NQ compounds that showed the best algicidal activity on target cyanobacteria, including Aphanizomenon, Dolichospermum, Microcystis, Oscillatoria, and Nostoc species. The compound NQ 2-0 showed the highest algicidal activity (90%) at a low concentration (>= 1 mu M) on target algae. These were very limiting algicidal effects of 1 mu M NQ 2-0 observed against non-target algae, such as diatoms (Stephanodiscus hantzschii, Cyclotella meneghiniana, Synedra acus, and Aulacoseira granulata) or green algae (Cosmarium biocuiatum and Scenedesmus quadricauda), and the effect did not exceed 15-25% (except against S. quadricauda). NQ 2-0 (1 mu M) showed no eco-toxicity, as represented by the survival rates of Pseudokirchneriella subcapitata (100%), Daphnia magna (100%), and Danio rerio (100%). Additionally, a chronic eco-toxicity assessment showed no toxicity toward the survival, growth or reproduction of D. magna. Moreover, NQ 2-0 quickly dissipated from field water samples and had a half-life of approximately 3.2 days. These results suggest that NQ 2-0 could be a selective and ecologically safe algicide to mitigate harmful cyanobacterial blooms.