Structural and functional aspects of platelet-derived growth factor.
Structural and functional aspects of platelet-derived growth factor.
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DOI：
10.1038/bjc.1988.134
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发表时间：
1988-06
影响因子：
8.8
通讯作者：
Westermark, B
中科院分区：
文献类型：
--
作者：
Heldin, C H;Hammacher, A;Nister, M;Westermark, B
PDGF的产生在正常细胞和转化细胞中是常见的，这一发现表明PDGF在几种生理和病理条件下具有自分泌和旁分泌刺激细胞的功能。PDGF的两条链的mRNA表达是独立调节的。PDGF的不同二聚体形式具有不同的功能效应的事实表明，对PDGF的细胞应答可能比以前认为的更复杂，并且可能涉及与一种以上的受体结合。PDGF的细胞效应、生长刺激、皱褶和趋化性似乎主要与含B链的二聚体有关。PDGF-AA的功能仍有待阐明。
The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The fact that the different dimeric forms of PDGF have different functional effects, indicate that the cellular response to PDGF may be more complex than previously thought, and may involve binding to more than one receptor. The cellular effects ascribed to PDGF, growth stimulation, ruffling and chemotaxis, seems to be mainly associated with B chain containing dimers. The function of PDGF-AA remains to be elucidated.