The expression and function of organic anion transporting polypeptides in normal tissues and in cancer.
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer.
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DOI：
10.1146/annurev-pharmtox-010510-100556
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发表时间：
2012
影响因子：
12.5
通讯作者：
Hagenbuch B
中科院分区：
文献类型：
--
作者：
Obaidat A;Roth M;Hagenbuch B
有机阴离子转运多肽（OATP）是SLCO基因蛋白质超家族的成员。根据氨基酸序列的相似性，将11种人OATP分为6个家族和亚家族。OATP在全身的几种上皮组织中表达，主要转运分子量超过300 kDa的两亲分子。OATP1和OATP2家族的成员是功能上最具特征的OATP。其中包括多特异性OATP1A2、OATP1B1、OATP1B3和OATP2B1。它们运输各种内源性和外源性物质，包括激素及其缀合物以及许多药物，如几种抗癌剂。最近的报道表明，一些OATP在几种癌症中上调或下调，并且OATP表达可能影响癌症的发展。在此综述中总结的结果的基础上，我们建议OATPs可能是有价值的抗癌治疗靶点。
Organic anion transporting polypeptides (OATPs) are members of the SLCO gene superfamily of proteins. The 11 human OATPs are classified in 6 families and subfamilies on the basis of their amino acid sequence similarities. OATPs are expressed in several epithelial tissues throughout the body and transport mainly amphipathic molecules with molecular weights of more than 300 kDa. Members of the OATP1 and OATP2 families are functionally the best-characterized OATPs. Among these are the multispecific OATP1A2, OATP1B1, OATP1B3, and OATP2B1. They transport various endo- and xenobiotics, including hormones and their conjugates as well as numerous drugs such as several anticancer agents. Recent reports demonstrate that some OATPs are up- or downregulated in several cancers and that OATP expression might affect cancer development. On the basis of the findings summarized in this review, we propose that OATPs could be valuable targets for anticancer therapy.
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DOI：
10.1124/jpet.106.104364
发表时间：
2006-08-01
影响因子：
3.5
作者：
Badagnani, Ilaria;Castro, Richard A.;Giacomini, Kathleen M.
通讯作者：
Giacomini, Kathleen M.
影响因子：
3.3
作者：
Choi, Koyi;Zhuang, Hean;Dore, Sylvain
通讯作者：
Dore, Sylvain
影响因子：
6.7
作者：
Glaeser, H.;Bailey, D. G.;Kim, R. B.
通讯作者：
Kim, R. B.
影响因子：
3.8
作者：
Feng, Bo;Xu, Jinghai J.;Wang, Huifen F.
通讯作者：
Wang, Huifen F.
影响因子：
4.5
作者：
Hagenbuch, B;Meier, PJ
通讯作者：
Meier, PJ