Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage
Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage
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DOI：
10.1159/000201562
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Lee, S. J.
中科院分区：
文献类型：
--
作者：
Jeon, H. Y.;Kim, J. K.;Lee, S. J.
背景/目的：过度暴露于紫外线辐射会引起急性不良反应，如晒伤和光敏反应，并参与诱发和发展皮肤癌。据报道，抗氧化剂对太阳紫外线辐射具有光防护作用。我们研究了口服没食子儿茶素没食子酸酯（EGCG）对最小红斑剂量（MED）和紫外线诱导的皮肤损伤的影响，EGCG是绿茶中的一种强大的抗氧化剂。方法：雌性HWY/Slc无毛大鼠在正常饲料中添加1500 ppm EGCG，饲喂8周；然后，测定MED，并评估视觉评分和经皮失水，以评估紫外线引起的皮肤损伤的严重程度。结果：在研究的第8周，饮食中使用EGCG显著增加了MED。补充EGCG也减轻了紫外线辐射引起的晒伤严重程度和表皮屏障功能的改变。结论：经常摄入EGCG可通过增加MED增强皮肤耐受性，从而防止紫外线引起的表皮屏障功能紊乱和皮肤损伤。这些结果表明EGCG是系统光保护的有效候选者。版权所有(C) 2009 S. Karger AG，巴塞尔
Background/Aims: Excessive exposure to UV radiation causes acute adverse effects like sunburn and photosensitivity reactions and is involved in the induction and development of skin cancer. It has been reported that antioxidants have photoprotective effects against solar UV radiation. We investigated the effect of oral epigallocatechin gallate (EGCG), a powerful antioxidant in green tea, on the minimal erythema dose (MED) and UV-induced skin damage. Method: Female HWY/Slc hairless rats were fed the normal diet supplemented with 1,500 ppm EGCG for 8 weeks; then, the MED was determined and visual scores and transepidermal water loss were assessed to evaluate the severity of UV-induced skin damage. Results: At week 8 of the study, the use of dietary EGCG significantly increased MED. UV-radiation-induced sunburn severity and alterations in epidermal barrier function were also attenuated by the supplementation of EGCG. Conclusion: Regular intake of EGCG strengthens the skin's tolerance by increasing MED and thus prevents UV-induced perturbation of epidermal barrier function and skin damage. These results suggest that EGCG is a potent candidate for systemic photoprotection. Copyright (C) 2009 S. Karger AG, Basel