Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives
Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives
复制标题
骨髓微转移和循环肿瘤细胞：当前方面和未来前景
作者：
V. Müller;K. Pantel
通过敏感的免疫细胞化学和分子检测，可以揭示乳腺癌患者单细胞水平的早期肿瘤细胞播散。最近涉及4000多名乳腺癌患者的临床研究表明，原发性诊断时骨髓中弥散性肿瘤细胞的存在是一个独立的预后因素。此外，最近开发了各种检测外周血循环肿瘤细胞的方法，一些研究也表明这种方法具有潜在的临床意义。这些发现为骨髓或血液中弥散性肿瘤细胞作为前瞻性临床试验中早期评估治疗反应的标志物提供了潜在的基础。
Early tumor cell dissemination at the single-cell level can be revealed in patients with breast cancer by using sensitive immunocytochemical and molecular assays. Recent clinical studies involving more than 4000 breast cancer patients demonstrated that the presence of disseminated tumor cells in bone marrow at primary diagnosis is an independent prognostic factor. In addition, various assays for the detection of circulating tumor cells in the peripheral blood have recently been developed and some studies also suggest a potential clinical relevance of this measure. These findings provide the basis for the potential use of disseminated tumor cells in bone marrow or blood as markers for the early assessment of therapeutic response in prospective clinical trials.