Insecticidal activity of penitrems, including penitrem G, a new member of the family isolated from Penicillium crustosum
Insecticidal activity of penitrems, including penitrem G, a new member of the family isolated from Penicillium crustosum
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DOI：
10.1021/jf020983e
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发表时间：
2003-04-09
影响因子：
6.1
通讯作者：
Yúfera, EP
中科院分区：
文献类型：
--
作者：
González, MC;Lull, C;Yúfera, EP
从壳青霉（PenicilliumcrustosumThom）的菌丝体中分离得到一种新的吲哚二萜类化合物青霉烯G（7），以及已知的真菌毒素青霉烯A ~ D（1-4）和青霉烯F（6）。根据光谱数据确定了青霉烯G的结构。此外，还分离出了另一种吲哚类二萜真菌毒素雀稗碱（8），该毒素以前未在该真菌中描述过。测试了这些化合物对半翅目Oncopeltus fasciatus达拉斯和双翅目Ceratitis capitata Wiedemann的杀虫活性。Penitrems A-D和F对这两种昆虫均表现出惊厥和杀虫活性。此外，存活的C.观察capitata雌性。相反，penitrem G和paspaline没有显示出任何活性。死亡率数据和亚致死的治疗效果，允许初步的结构-活性关系提出。
Penitrem G (7), a new indole-diterpenoid compound, has been isolated together with the already known mycotoxins penitrems A-D (1-4) and F (6) from the mycelium of Penicillium crustosum Thom. The structure of penitrem G was established on the basis of spectroscopic data. In addition, paspaline (8), another indole-diterpenoid mycotoxin that has not been previously described in this fungus, was also isolated. These compounds were tested for insecticidal activity against the hemipteran Oncopeltus fasciatus Dallas and the dipteran Ceratitis capitata Wiedemann. Penitrems A-D and F showed convulsive and insecticidal activities against both insect species. In addition, important reductions in the fecundity and fertility of the surviving C. capitata females were observed. In contrast, penitrem G and paspaline did not show any kind of activity. Mortality data and sublethal effects of the treatments have allowed preliminary structure-activity relationships to be proposed.