On-center/inhibitory-surround decorrelation via intraglomerular inhibition in the olfactory bulb glomerular layer
On-center/inhibitory-surround decorrelation via intraglomerular inhibition in the olfactory bulb glomerular layer
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DOI：
10.3389/fnint.2012.00005
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发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
Linster, Christiane
中科院分区：
文献类型：
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作者：
Cleland, Thomas A.;Linster, Christiane
经典的侧抑制依赖于物理刺激的空间有序的神经表征，不能去相关的感觉表征，其中刺激属性被表示为非地形。最近的理论和实验研究表明，这种非地形表示的嗅觉刺激占主导地位的嗅球，从而驳斥了经典的观点，嗅觉去相关是由侧抑制相当于在视网膜。然而，问题仍然存在，关于如何以及非地形去相关模型可以复制的抑制性“包围”，已被实验观察到的嗅球主神经元（相对于气味特征相似性），类似于视网膜中的侧抑制产生的空间抑制性包围。使用两个对比的情况下，刺激代表一个“retinotopically”组织和一个感受野是不可预测的分布，因为它们是在嗅球，我们在这里表明，局部中间神经元和主神经元之间的抑制相互作用，成功地去相关类似的感觉表示，无论场景的代表。相反，相邻列中这些相同神经元之间的侧抑制相互作用只能有效地去相关拓扑组织的表示。虽然解剖基板表面上与这两种类型的抑制存在于嗅球，只有本地intragglomerular抑制足以调解嗅觉去相关。
Classical lateral inhibition, which relies on spatially ordered neural representations of physical stimuli, cannot decorrelate sensory representations in which stimulus properties are represented non-topographically. Recent theoretical and experimental studies indicate that such a non-topographical representation of olfactory stimuli predominates in olfactory bulb, thereby refuting the classical view that olfactory decorrelation is mediated by lateral inhibition comparable to that in the retina. Questions persist, however, regarding how well non-topographical decorrelation models can replicate the inhibitory "surround" that has been observed experimentally (with respect to odor feature-similarity) in olfactory bulb principal neurons, analogous to the spatial inhibitory surround generated by lateral inhibition in retina. Using two contrasting scenarios of stimulus representation one "retinotopically" organized and one in which receptive fields are unpredictably distributed as they are in olfactory bulb we here show that intracolumnar inhibitory interactions between local interneurons and principal neurons successfully decorrelate similar sensory representations irrespective of the scenario of representation. In contrast, lateral inhibitory interactions between these same neurons in neighboring columns are only able to effectively decorrelate topographically organized representations. While anatomical substrates superficially consistent with both types of inhibition exist in olfactory bulb, of the two only local intraglomerular inhibition suffices to mediate olfactory decorrelation.