Palladium Catalyzed Enantioselective Hayashi-Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-dihydrocoumarins.
Palladium Catalyzed Enantioselective Hayashi-Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-dihydrocoumarins.
复制标题
DOI：
10.26434/chemrxiv-2021-z32hb
复制
发表时间：
2021-11
期刊：
影响因子：
5.2
通讯作者：
J. Lai;Chen-Hwa Yang;R. Csuk;Baoan Song;Shengkun Li
中科院分区：
文献类型：
--
作者：
J. Lai;Chen-Hwa Yang;R. Csuk;Baoan Song;Shengkun Li
本文首次成功地建立了钯催化芳香硼酸对香豆素的不对称加成反应，为合成具有重要药理意义的4-芳基-3,4-二氢香豆素提供了一种直接的不对称方法。该方法具有易于获取和稳定的配体、广泛的底物范围、温和的条件和吸电子芳基硼酸的适应性。
The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions, and accommodation of electron-withdrawing arylboronic acids.