Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393.
Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393.
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多巴胺 D1 受体介导 SKF 38393 的辨别刺激特性。
DOI：
10.1016/0014-2999(85)90330-9
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发表时间：
1985
影响因子：
5
通讯作者：
Appel,JB
中科院分区：
文献类型：
--
作者：
Cunningham,KA;Callahan,PM;Appel,JB
在双水平药物识别任务中，分析了SKF 38393的多巴胺能介导刺激特性。在获得SKF 38393 （10 mg/kg）与生理盐水的区分能力后，大鼠（N= 12）与选择性d1和d2受体激动剂和拮抗剂进行替代（泛化）和联合（拮抗）试验。2拮抗剂阿波啡和Ly 171555 （Ly 141865的左旋异构体）主要产生盐水平反应；d1拮抗剂Sch 23390，而不是d2拮抗剂氟哌啶醇，剂量依赖性地拮抗SKF 38393提示。这些数据支持了之前的神经化学和行为研究表明SKF 38393可能通过刺激d1受体起作用。
Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N= 12) were given substitution (generalization) and combination (antagonism) tests with selective D1and D2receptor agonists and antagonists. The D2agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1antagonist Sch 23390, but not the D2antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1receptors.