The plasticity of dendritic cell responses to pathogens and their components
The plasticity of dendritic cell responses to pathogens and their components
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DOI：
10.1126/science.294.5543.870
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发表时间：
2001-10-26
期刊：
影响因子：
56.9
通讯作者：
Hacohen, N
中科院分区：
文献类型：
--
作者：
Huang, Q;Liu, DY;Hacohen, N
树突状细胞参与了先天性免疫和适应性免疫的启动。为了系统地探索树突状细胞如何调节免疫系统以应对不同的病原体，我们使用寡核苷酸芯片测量了树突状细胞对大肠杆菌、白色念珠菌和流感病毒及其分子成分的基因表达谱。在接触这些病原体时，既观察到了共同的核心反应，也观察到了病原体特异性基因表达程序。这些结果表明，树突状细胞能感知不同的病原体，并引起定制的病原体特异性免疫反应。
Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.