The relative impact and future burden of prostate cancer in the United States.
The relative impact and future burden of prostate cancer in the United States.
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DOI：
10.1097/01.ju.0000142068.66876.53
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发表时间：
2004-11-01
期刊：
影响因子：
--
通讯作者：
Carroll, Peter R
中科院分区：
文献类型：
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作者：
Chan, June M;Jou, Ronald M;Carroll, Peter R
目的：在过去的20年里，人们对前列腺癌的认识和研究不断增加。材料和方法：使用监测、流行病学和最终结果和其他政府数据库来1)比较前列腺癌与其他癌症和主要死因的发病率和死亡负担；2)使用连接点分析检查前列腺癌死亡率的变化趋势；3)考虑美国未来因老龄化而造成的前列腺癌负担。为了预测前列腺癌的未来负担，美国人口普查局对2000年的死亡率进行了年龄别人口预测。结果：前列腺癌仍然是美国男性所有癌症中发病率最高、死亡率第二高的癌症，它是所有死亡原因中的前十名。前列腺癌死亡率自1994年以来以每年4%左右的速度稳步下降，而发病率自1995年以来以每年略低于2%的速度递增。结论：1994年以来前列腺癌死亡率的总体下降可能是由于筛查、诊断和治疗水平的提高。尽管死亡率在下降，但美国人口老龄化和前列腺癌发病率和死亡率按年龄呈指数增长，在评估这种疾病未来的发病率和死亡率负担以及卫生保健资源的适当分配时都是重要的。
PURPOSE: In the last 2 decades there has been increasing awareness of and research on prostate cancer. We considered prostate cancer in the context of other major causes of morbidity and mortality.MATERIALS AND METHODS: Surveillance, Epidemiology, and End Results, and other government databases were used to 1) compare the incidence and mortality burden of prostate cancer with that of other cancers and major causes of death; 2) examine the changing trends in prostate cancer mortality using joinpoint analysis and 3) consider the future burden of prostate cancer in the United States due to aging. To project the future burden of prostate cancer year 2000 mortality rates were applied to age specific population projections from the United States Census Bureau.RESULTS: Prostate cancer continues to have the highest incidence rate and the second highest mortality rate of any cancer in American men and it ranks among the top 10 overall causes of death. The mortality rate of prostate cancer has been decreasing steadily at approximately 4% yearly since 1994, while the incidence rate has been increasing at slightly less than 2% yearly since 1995.CONCLUSIONS: The overall decrease in the mortality rate of prostate cancer since 1994 may be due to improvements in screening, diagnosis and treatments. Despite the decreasing mortality rate the aging of the American population and the exponential increase in prostate cancer incidence and mortality rates by age are important to consider when assessing the future morbidity and mortality burden of this disease and the appropriate allocation of health care resources.