Evidence of increased oxidative stress, unexplained by lipid changes, is present in nulliparous black women from early gestation
Evidence of increased oxidative stress, unexplained by lipid changes, is present in nulliparous black women from early gestation
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DOI：
10.1081/prg-120028285
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发表时间：
2004-01-01
影响因子：
1.5
通讯作者：
Roberts, JM
中科院分区：
文献类型：
--
作者：
Patrick, TE;Hubel, CA;Roberts, JM
目的：我们验证了一种假设，即妊娠期间特定种族的血脂变化易导致氧化应激，并可能增加黑人女性先兆子痫的风险。研究设计：对15名正常妊娠的黑人和15名白人妇女在孕期和产后5个时间点采集血样。分析血清或血浆样本中的胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白总及其亚组分、游离脂肪酸、尿酸和丙二醛。结果：在整个妊娠期间，白人女性的胆固醇和低密度脂蛋白-胆固醇值高于黑人女性(RMANOVA，p=0.04)，而黑人女性的MDA值则高于黑人女性(RMANOVA，p=0.03)。尽管没有显著差异，但黑人女性的平均甘油三酯较低，而黑人女性的平均总高密度脂蛋白及其亚组分HDL2和HDL3较高。随着妊娠的提前，两个种族都表现出更小、更致密的低密度脂蛋白颗粒大小，并在怀孕6周时恢复到早孕低密度脂蛋白颗粒大小。结论：这些数据不支持将定量的血脂变化作为黑人妇女先兆子痫发病率增加的解释。尽管如此，黑人女性表现出越来越多的氧化应激证据，被认为是妊娠早期先兆子痫发病的重要因素。
Objective: We tested the hypothesis that race-specific lipid changes in pregnancy could predispose to oxidative stress and might increase the risk of preeclampsia for black women. Study Design: Blood samples were obtained at five time points in pregnancy and postpartum for 15 black and 15 white women with normal pregnancy. Serum or plasma samples were analyzed for cholesterol, triglycerides, LDL cholesterol, HDL total and subfractions, free fatty acids, uric acid, and malondialdehyde (MDA). Results: Cholesterol and LDL-cholesterol values were higher in white women than in black women (RMANOVA, p = 0.04) while MDA values were higher in blacks throughout pregnancy (RMANOVA, p = 0.03). Although not significantly different, black women had lower mean triglycerides, while mean total HDL and subfractions HDL2 and HDL3 were higher for black women. Both races evidenced smaller, denser LDL particle size with advancing gestation and a return to early pregnancy LDL particle size by 6 weeks' gestation. Conclusion: These data do not support quantitative lipid change as the explanation for the increased incidence of preeclampsia in black women. Despite this, black women manifest increased evidence of oxidative stress, postulated to be an important contributor to the pathogenesis of preeclampsia from early gestation.