A submucosal variant of Whipple's disease
A submucosal variant of Whipple's disease
复制标题
Whipple 病的粘膜下变异型
DOI：
10.1016/0016-5085(82)90121-4
复制
发表时间：
1982
期刊：
影响因子：
29.4
通讯作者：
G. Hutchins
中科院分区：
文献类型：
--
作者：
F. Kuhajda;F. Kuhajda;N. Belitsos;N. Belitsos;D. Keren;D. Keren;G. Hutchins;G. Hutchins
我们描述了一个不寻常的惠普尔氏病病例，患者先前接受过结核病治疗，其小肠受累仅限于粘膜下层。这具有诊断重要性，因为在这种情况下，除非对粘膜下层进行充分取样，否则无法通过空肠活检确定惠普尔氏病的存在。肠道感染的这种异常分布可能与抗生素治疗的效果有关。对患者血清胆固醇、胡萝卜素和白蛋白的回顾性研究表明，尽管粘膜没有感染，惠普尔病也可能出现吸收不良。
We describe an unusual case of Whipple's disease, in a patient previously treated for tuberculosis, in which involvement of the small intestine was restricted to the submucosa. This is of diagnostic importance since the presence of Whipple's disease cannot be established by jejunal biopsy in such cases unless the submucosa is adequately sampled. It is possible that this unusual distribution of intestinal infection is related to the effects of the antibiotic therapy. Retrospective study of the patient's serum cholesterol, carotene, and albumin suggests that malabsorption may occur in Whipple's disease despite the absence of infection in the mucosa.