Mesangiocapillary glomerulonephritis caused by Puumala hantavirus infection
Mesangiocapillary glomerulonephritis caused by Puumala hantavirus infection
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DOI：
10.1159/000046111
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发表时间：
2001-12-01
期刊：
影响因子：
2.5
通讯作者：
Pasternack, A
中科院分区：
文献类型：
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作者：
Mustonen, J;Mäkelä, S;Pasternack, A
由普氏汉坦病毒引起的肾病流行可引起急性可逆性肾功能损害。典型的肾活检发现是急性肾小管间质性肾炎伴轻微肾小球系膜改变。我们在这里描述了5例在恢复期发展肾病综合征的患者，否则典型的急性热性肾病流行。所有患者的肾活检显示为I型血管毛细血管肾小球肾炎（MCGN）。随访期间4例患者肾病综合征临床缓解，1例进入慢性肾功能衰竭。3例患者有血尿和蛋白尿，2例血压升高。没有患者的临床或实验室结果与慢性细菌、寄生虫或病毒感染（乙型或丙型肝炎）、恶性肿瘤或其他已知与MCGN相关的疾病相一致。总之，必须将普马拉汉坦病毒添加到与I型MCGN相关的潜在病原体列表中。需要进一步研究以确定各种汉坦病毒感染引起MCGN的发生率。版权所有(C) 2001 S. Karger AG，巴塞尔
Nephropathia epidemica induced by Puumala hantavirus typically causes acute reversible renal function impairment. A typical renal biopsy finding is acute tubulointerstitial nephritis with slight glomerular mesangial changes. We describe here 5 patients who developed the nephrotic syndrome during the convalescent phase of an otherwise typical acute febrile nephropathia epidemica. Renal biopsy of all patients disclosed type I mesangiocapillary glomerulonephritis (MCGN). A clinical remission of the nephrotic syndrome was observed in 4 patients during the follow-up period, and 1 entered into chronic renal failure. Three patients had microscopic hematuria and proteinuria and 2 elevated blood pressure at the latest assessment visit. No patient had clinical or laboratory findings compatible with chronic bacterial, parasitic or viral infections (hepatitis B or C), malignancies, or other disorders known to be associated with MCGN. In conclusion, Puumala hantavirus has to be added to the list of potential agents associated with type I MCGN. Further studies are necessary to establish the incidence of MCGN caused by various hantavirus infections. Copyright (C) 2001 S. Karger AG, Basel.