Prefrontal Cortex Activation While Walking Under Dual-Task Conditions in Stroke: A Multimodal Imaging Study.
Prefrontal Cortex Activation While Walking Under Dual-Task Conditions in Stroke: A Multimodal Imaging Study.
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DOI：
10.1177/1545968315613864
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发表时间：
2016-07
影响因子：
4.2
通讯作者：
Dawes H
中科院分区：
文献类型：
--
作者：
Al-Yahya E;Johansen-Berg H;Kischka U;Zarei M;Cockburn J;Dawes H
对于许多中风幸存者来说，边走边执行另一项任务(如说话)是一种挑战，但其神经基础还没有完全被理解。研究卒中幸存者在单任务(ST)和双任务(DT)条件下行走时前额叶皮质的激活及其与步态测量的关系。我们采集了慢性中风幸存者和健康对照组在ST和DT条件下跑步机行走时前额叶皮质的近红外光谱(NIRS)数据。我们还在这些条件下模拟步行过程中进行了功能磁共振成像(FMRI)和近红外光谱(NIRS)检查。NIRS显示，两组患者在DT步行时的氧合血红蛋白浓度均高于ST步行时。对于模拟步行，NIRS在卒中存活者中显示出显著的组和组×任务效应，且这两种效应都更大。从ST步行到DT步行/模拟步行观察到的大脑激活的更大增加与中风幸存者运动能力的更大变化有关。功能磁共振成像显示中风患者在DT期间比ST状态下双侧颞叶下回、额叶上回和扣带回以及右侧中央前回的活动增加。中风患者双侧颞下回、左侧扣带回和左额极的DT相关的fMRI活动增加与DT相关的行为改变相关。我们的结果提供了新的证据，表明大脑活动的增强变化与双重任务运动减少有关。
Walking while performing another task (eg, talking) is challenging for many stroke survivors, yet its neural basis are not fully understood. To investigate prefrontal cortex activation and its relationship to gait measures while walking under single-task (ST) and dual-task (DT) conditions (ie, walking while simultaneously performing a cognitive task) in stroke survivors. We acquired near-infrared spectroscopy (NIRS) data from the prefrontal cortex during treadmill walking in ST and DT conditions in chronic stroke survivors and healthy controls. We also acquired functional magnetic resonance imaging (fMRI) and NIRS during simulated walking under these conditions. NIRS revealed increased oxygenated hemoglobin concentration in DT-walking compared with ST-walking for both groups. For simulated walking, NIRS showed a significant effect of group and group × task, being greater on both occasions, in stroke survivors. A greater increase in brain activation observed from ST to DT walking/ simulated walking was related to a greater change in motor performance in stroke survivors. fMRI revealed increased activity during DT relative to ST conditions in stroke patients in areas including the inferior temporal gyri, superior frontal gyri and cingulate gyri bilaterally, and the right precentral gyrus. The DT-related increase in fMRI activity correlated with DT-related change in behavior in stroke participants in the bilateral inferior temporal gyrus, left cingulate gyrus, and left frontal pole. Our results provide novel evidence that enhanced brain activity changes relate to dual task motor decrements.