EFFECTS OF CONTINUOUS VERSUS LIMITED ACCESS TO ETHANOL ON ETHANOL SELF-ADMINISTRATION
EFFECTS OF CONTINUOUS VERSUS LIMITED ACCESS TO ETHANOL ON ETHANOL SELF-ADMINISTRATION
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DOI：
10.1016/0741-8329(94)90079-5
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发表时间：
1994-11-01
期刊：
影响因子：
2.3
通讯作者：
SAMSON, HH
中科院分区：
文献类型：
--
作者：
FILES, FJ;LEWIS, RS;SAMSON, HH
8只雄性实验幼年龙-埃文斯大鼠在开始自我注射乙醇后，每天在操作室中饲养23小时。在饲养期间，动物可以根据固定比例1的强化计划连续获得食物颗粒，根据固定比例4的强化计划连续获得10%乙醇（v/v）和饮水管中的水，并通过饮水计记录舔水。在一系列的实验阶段，乙醇溶液的每日可用性被限制为每天16、6、4、2或1 30分钟。在每日会议的第12小时或第2小时审查130分钟的访问时间。在整个实验过程中，随着每日接触次数的减少，操作斗的杠杆上的总反应、每天的g/kg和每天的乙醇饮用次数显著减少。另一方面，每次乙醇回合的浸出量、每乙醇回合的g/kg和乙醇回合持续时间均增加，当每天提供一个30分钟的接触时间时，每次回合的浸出量显著增加。这些数据表明，通过限制获得乙醇强化剂的机会，可以在一定程度上增加一次乙醇饮酒的量，这与早期显示出类似效果的研究结果一致。
Eight male, experimentally naive Long-Evans rats were housed in operant chambers 23 h per day following initiation to self-administer ethanol. While housed in the chambers, the animals had continuous access to food pellets according to a fixed ratio 1 schedule of reinforcement, 10% ethanol (v/v) according to a fixed ratio 4 schedule of reinforcement and water in a drinking tube with licks recorded via a drinkometer. Over a series of experimental phases, daily availability of the ethanol solution was limited to 16, 6, 4, 2, or 1 30-min period per day. The 1 30-min period access was examined during the 12th hour or the second hour of the daily sessions. Over the course of the experiment, total responses on the lever that operated the dipper, g/kg per day and number of ethanol drinking bouts per day decreased significantly as the number of daily access periods decreased. On the other hand, the number of dippers presented per ethanol bout, g/kg per ethanol bout and ethanol bout duration increased, with significant increases in dippers per bout occurring when one 30-min access period per day was provided. These data indicate that the size of a single ethanol drinking bout can be increased somewhat by limiting the opportunity to obtain ethanol reinforcement and agrees with earlier research that has shown similar effects.