Familial risks for type 2 diabetes in Sweden.
Familial risks for type 2 diabetes in Sweden.
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DOI：
10.2337/dc09-0947
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发表时间：
2010-02
期刊：
影响因子：
16.2
通讯作者：
Sundquist J
中科院分区：
文献类型：
--
作者：
Hemminki K;Li X;Sundquist K;Sundquist J
我们的目的是通过受影响的家庭成员的类型和数量来描述2型糖尿病的家庭风险，包括同父异母的兄弟姐妹，被收养者和配偶，以量化风险并估计环境影响的贡献。从多代登记册中确定家庭，从医院出院登记册中获得2型糖尿病患者。标准化的发病率计算与2型糖尿病的后代相比，其家庭成员在年龄>39岁时因2型糖尿病住院，与那些没有受影响的家庭成员。住院的2型糖尿病患者人数为157，549人。在27,895名子女中，27.9%的父母或兄弟姐妹也因2型糖尿病住院。家族性相对危险度（RR）范围为2.0至>30，取决于先证者的数量和类型。2型糖尿病的RR最高的是那些至少有两个兄弟姐妹受2型糖尿病影响的人，无论父母的疾病如何。被收养者没有受到养父母的威胁。这项研究是迄今为止发表的最大规模的研究，表明家族性RR因受影响家庭成员的数量和类型而异。然而，大部分的家族聚集性仍然有待遗传学解释。在临床遗传咨询中应认识到这一高风险。被收养者的数据证实了家庭关联的遗传基础，但那些来自半同胞和配偶的数据表明，家庭聚集的一小部分可能是由环境因素造成的。
Our aim was to characterize familial risks for type 2 diabetes by the type and number of affected family members, including half-siblings, adoptees, and spouses, to quantify risks and estimate the contribution of environmental effect. Families were identified from the Multigeneration Register, and type 2 diabetic patients were obtained from the Hospital Discharge Register. Standardized incidence ratios were calculated for offspring with type 2 diabetes whose family members were hospitalized for type 2 diabetes at ages >39 years compared with those lacking affected family members. The number of hospitalized type 2 diabetic patients was 157,549. Among 27,895 offspring, 27.9% had a parent or sibling also hospitalized for type 2 diabetes. The familial relative risk (RR) ranged from 2.0 to >30, depending on the number and type of probands. The highest RRs of type 2 diabetes were found in individuals who had at least two siblings affected by type 2 diabetes, irrespective of the parental disease. Adoptees showed no risk from adopted parents. The study, the largest yet published, showed that familial RRs varied by the number and type of affected family member. However, much of the familial clustering remains yet to be genetically explained. The high risk should be recognized in clinical genetic counseling. The data from adoptees confirmed the genetic basis of the familial associations, but those from half siblings and spouses suggested that a smaller part of familial clustering may be accounted for by environmental factors.