Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
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DOI：
10.1371/journal.pone.0077446
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Ji F;Li Z;Young JN;Yeranossian A;Liu H
和目标：本回顾性研究的目的是研究慢性肾脏疾病、急性肾损伤（阿基）与接受心脏手术的患者在旁路术后使用右美托咪定的潜在获益之间的关系。经IRB批准后，从机构胸外科医师协会国家成人心脏手术数据库中审查患者数据。确定了1，133名患者，并将其分为两组：接受右美托咪定的患者或在搭桥术后期间未接受右美托咪定的患者。术后结局包括阿基的发生率、任何并发症和全因死亡率。旁路术后右美托咪定的使用与总阿基发生率显著降低相关（26.1% vs. 33.75%;校正OR，0.7033; 95%CI，0.540 - 0.916; p=0.0089）。此外，旁路术后使用右美托咪定更可能降低这些术前肾功能正常（1期; 32.8%至22.8%; p=0.0233）和心脏手术后轻度CKD（2期; 32.8%至24.7; p=0.0003）患者的阿基发生率。旁路术后输注右美托咪定与任何并发症的发生率和30天死亡率显著降低相关。旁路术后使用右美托咪定可显著降低阿基的发生率，尤其是在术前肾功能正常和接受心脏手术的轻度CKD患者中的轻度阿基。
And Objectives: The aim of this retrospective investigation was to study the relationships among chronic kidney disease, acute kidney injury (AKI), and potential benefits by post-bypass dexmedetomidine use in patients undergoing cardiac surgery. The patient data were reviewed from the institutional Society of Thoracic Surgeons National Adult Cardiac Surgery Database after IRB approval. 1,133 patients were identified and divided into two groups: those who received dexmedetomidine or those who did not during the post-bypass period. The postoperative outcomes include the incidence of AKI, any complication and all cause of mortality. Post-bypass dexmedetomidine use was associated with significantly reduced the incidence of total AKI (26.1% vs. 33.75%; adjusted OR, 0.7033; 95%CI, 0.540 to 0.916; p=0.0089). In addition, post-bypass dexmedetomidine use was more likely to reduce the incidence of AKI in these patients with preoperative normal kidney function (Stage1; 32.8% to 22.8%; p=0.0233) and mild CKD (Stage 2; 32.8% to 24.7; p=0.0003) after cardiac surgery. Post-bypass infusion of dexmedetomidine was associated with significantly reduced incidence of any complication and 30-day mortalities. Post-bypass dexmedetomidine use is associated with a significant reduction in the incidence of AKI, especially mild AKI in patients with preoperative normal renal function and mild CKD undergoing cardiac surgery.
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影响因子：
2.2
作者：
Leino K;Hynynen M;Jalonen J;Salmenperä M;Scheinin H;Aantaa R;Dexmedetomidine in Cardiac Surgery Study Group
通讯作者：
Dexmedetomidine in Cardiac Surgery Study Group
DOI：
10.1152/ajprenal.00143.2012
发表时间：
2012-11-01
影响因子：
4.2
作者：
Hsing, Chung-Hsi;Lin, Chiou-Feng;Yeh, Ching-Hua
通讯作者：
Yeh, Ching-Hua
影响因子：
8.8
作者：
Shirasaka, Tetsuro;Kannan, Hiroshi;Takasaki, Mayumi
通讯作者：
Takasaki, Mayumi
影响因子：
6.7
作者：
Frumento, Robert J.;Logginidou, HeLene G.;Sladen, Robert N.
通讯作者：
Sladen, Robert N.
影响因子：
8.8
作者：
Sanders, Robert D.;Xu, Jing;Maze, Mervyn
通讯作者：
Maze, Mervyn