A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity.
A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity.
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Gur 是小鼠 β-葡萄糖醛酸酶诱导的调节位点，控制信使 RNA 活性。
DOI：
10.1126/science.760204
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发表时间：
1979
期刊：
影响因子：
56.9
通讯作者：
G. Watson
中科院分区：
文献类型：
--
作者：
K. Paigen;C. Labarca;G. Watson
高等生物中的一个调控位点已被证明可以控制特定的信使RNA活性。小鼠的Gur基因座在睾丸激素诱导β -葡糖醛酸酶结构基因Gus后调节肾脏β -葡糖醛酸酶信使RNA活性的产生。研究了β -葡糖醛酸酶信使RNA在爪蟾卵母细胞中指导催化活性小鼠β -葡糖醛酸酶合成的能力。
A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.