Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade
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DOI：
10.1016/j.bbrc.2007.08.190
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发表时间：
2007-11-16
影响因子：
3.1
通讯作者：
Tan, Man-Wah
中科院分区：
文献类型：
--
作者：
Kurz, C. Leopold;Shapira, Michael;Tan, Man-Wah
动物和植物通过诱导重叠的防御基因来应对细菌感染和环境压力。与感染和非生物应激相关的信号如何在整个生物体内不同地整合仍有待充分解决。我们发现秀丽隐杆线虫ABC转运体pgp-5的转录可被细菌感染和重金属胁迫诱导，但其表达的大小和组织分布不同，取决于胁迫源的类型。PGP-5有助于抵抗细菌感染和重金属。使用pgp-5转录作为读出，我们发现来自生物和非生物胁迫的信号都被TIR-1（一种与人类SARM同源的TIR结构域适配器蛋白）和p38 MAP激酶信号盒整合。我们进一步证明，并不是所有的TIR-1亚型都是线虫抵抗感染所必需的，这表明了对非生物和生物胁迫的不同反应的分子基础。(C) 2007爱思唯尔公司版权所有。
Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Caenorhabditis elegans ABC transporter, pgp-5 is induced by both bacterial infection and heavy metal stress, but the magnitude and tissue distribution of its expression differs, depending on the type of stressor. PGP-5 contributes to resistance to bacterial infection and heavy metals. Using pgp-5 transcription as a read-out, we show that signals from both biotic and abiotic stresses are integrated by TIR-1, a TIR domain adaptor protein orthologous to human SARM, and a p38 MAP kinase signaling cassette. We further demonstrate that not all the TIR-1 isoforms are necessary for nematode resistance to infection, suggesting a molecular basis for the differential response to abiotic and biotic stress. (C) 2007 Elsevier Inc. All rights reserved.