Early childhood mortality from community-acquired infections.
Early childhood mortality from community-acquired infections.
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社区获得性感染导致的幼儿死亡率。
DOI：
10.1093/oxfordjournals.aje.a010041
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发表时间：
1999
影响因子：
5
通讯作者：
W. Ray
中科院分区：
文献类型：
--
作者：
W. Cooper;G. Hickson;E. Mitchel;K. Edwards;P. Thapa;W. Ray
在这项研究中，作者确定了母婴特征，这些特征是社区获得的传染病死亡的独立预测因素，并确定这些因素是否可以用于识别感染死亡风险过高的儿童群体。对1985年至1994年(研究期间)在田纳西州出生并拥有完整出生证明信息的5岁以下儿童进行了历史队列研究。主要结果是从死亡证明中确定的感染死亡，并通过医疗记录审查确认。在1,014,976名5岁以下儿童中，有3,351,568名儿童在后续行动中，有247人死于感染(每10万名儿童中有7.4人死于感染)。呼吸道感染约占死亡人数的一半。有三个或更多的兄弟姐妹或出生体重低于1,500克的儿童死于感染的风险分别增加3倍和10倍，而具有这两个特征的儿童的风险增加近20倍，并持续到出生第一年。干预措施应侧重于预防易受感染儿童的这些感染。应针对高危儿童进行仔细的随访，并在出现感染迹象时及早住院。
In this study, the authors identified maternal and child characteristics that were independent predictors of death from infectious diseases acquired in the community and determined if these factors could be used to identify groups of children with excess risk of mortality from infection. A historical cohort study was conducted of children less than 5 years of age between 1985 and 1994 (the study period), who were born in Tennessee, and had complete information on their birth certificates. The primary outcome was death from infection identified from death certificates and confirmed through medical record review. Among the 1,014,976 children less than 5 years of age, who contributed 3,351,568 child-years of follow-up, there were 247 deaths from infections (7.4 deaths from infections per 100,000 child-years). Respiratory infections accounted for approximately one half of the deaths. Children having three or more older siblings or birth weight of less than 1,500 g had a 3-fold and 10-fold increased risk of death from infection, respectively, while children with both characteristics had a nearly 20-fold increased risk that persisted beyond the first year of life. Interventions should be focused on prevention of these infections in vulnerable children. At-risk children should be targeted for careful follow-up and early hospitalization when signs of infection develop.