Review of hypofractionated radiotherapy for prostate cancer.
Review of hypofractionated radiotherapy for prostate cancer.
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DOI：
10.5402/2012/410892
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kardamakis D
中科院分区：
文献类型：
--
作者：
Spyropoulou D;Kardamakis D
大分割放射治疗前列腺癌已成为越来越感兴趣的认识，在治疗结果的潜在改善与大规模的每日部分交付的治疗。此外，低分割提供了减少的分数，并产生有吸引力的成本和增加的方便患者。有令人信服的证据，通过几个临床试验，生化控制显着改善与更高的管理辐射剂量的前列腺。此外，改进的辐射递送技术，诸如3D适形放射疗法（3DCRT）或更好的调强放射疗法（IMRT）允许对前列腺施用高剂量，同时保留正常的周围组织。前列腺癌的放射生物学的几项研究表明，它可能更容易受到大的分数大小相比，传统的分割外束辐射。
Hypofractionated radiotherapy for prostate cancer has become of increasing interest with the recognition of a potential improvement in therapeutic outcome with treatments delivered in large-sized daily fractions. In addition, hypofractionation offers a reduction in fraction number and produces attractive cost and increased convenience for patients. There is convincing evidence, by several clinical trials, that biochemical control is significantly improved with higher administered radiation doses to the prostate gland. Furthermore, the improved radiation delivery techniques such as 3D conformal radiotherapy (3DCRT) or, better, intensity modulated radiation therapy (IMRT) allow high administered doses to the prostate while sparing the normal surrounding tissues. Several studies of the radiobiology of prostate cancer suggest that it may be more susceptible to large fraction sizes compared with conventional fractionation of external beam radiation.