Host−Guest Interaction between β-Cyclodextrin and Hydrophobically Modified Poly(isobutene-alt-maleic acid) Studied by Affinity Capillary Electrophoresis
Host−Guest Interaction between β-Cyclodextrin and Hydrophobically Modified Poly(isobutene-alt-maleic acid) Studied by Affinity Capillary Electrophoresis
复制标题
通过亲和毛细管电泳研究 β-环糊精和疏水改性聚（异丁烯-马来酸）之间的主客体相互作用
DOI：
10.1021/ma020270x
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发表时间：
2002
期刊：
影响因子：
5.5
通讯作者：
J. Jacquier
中科院分区：
文献类型：
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作者：
Bart Jan Ravoo and;J. Jacquier
对叔丁基苯基或金刚烷基修饰的聚异丁烯-马来酸酯与β-环糊精在水中相互作用，是由于β-环糊精空腔中包含疏水取代基。这些主客体复合物的形成进行了研究，在稀水溶液中使用亲和毛细管电泳。在毛细管中增加浓度的β-环糊精的存在下测量聚合物的电泳迁移率。结合常数K（以每摩尔β-环糊精表示）由聚合物的电泳迁移率随β-环糊精浓度的增加而变化来确定。对叔丁基苯基客体聚合物的K =（2.8−3.9）× 104 M-1，金刚烷基客体聚合物的K =（2.2−3.5）× 103 M-1。这些研究结果是一致的滴定微量热法的数据，表明毛细管电泳是一种合适的技术，定量测量与疏水改性聚合物的相互作用。选举的变化…
Poly(isobutene-alt-maleic acid)s modified with p-tert-butylphenyl or adamantyl groups interact with β-cyclodextrin in water due to inclusion of the hydrophobic substituents in the β-cyclodextrin cavity. The formation of these host−guest complexes was investigated in dilute aqueous solution using affinity capillary electrophoresis. The electrophoretic mobility of the polymers was measured in the presence of increasing concentration of β-cyclodextrin in the capillary. The binding constants K (expressed per mole of β-cyclodextrin) were determined from the change of the electrophoretic mobility of the polymers with the increase of β-cyclodextrin concentration. K = (2.8−3.9) × 104 M-1 for p-tert-butylphenyl guest polymers and K = (2.2−3.5) × 103 M-1 for adamantyl guest polymers. These findings are consistent with titration microcalorimetry data, demonstrating that capillary electrophoresis is a suitable technique to quantitatively measure interactions with hydrophobically modified polymers. The change in elect...