INFLUENCE OF THIAMIN SUPPLEMENTATION ON THE HEALTH AND GENERAL WELL-BEING OF AN ELDERLY IRISH POPULATION WITH MARGINAL THIAMIN DEFICIENCY
INFLUENCE OF THIAMIN SUPPLEMENTATION ON THE HEALTH AND GENERAL WELL-BEING OF AN ELDERLY IRISH POPULATION WITH MARGINAL THIAMIN DEFICIENCY
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DOI：
10.1093/geronj/46.1.m16
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
CLIFFORD, AJ
中科院分区：
文献类型：
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作者：
SMIDT, LJ;CREMIN, FM;CLIFFORD, AJ
研究了硫胺素补充对80名健康老年爱尔兰妇女的健康和总体幸福感的影响，这些妇女来自边缘硫胺素缺乏症人群。控制了影响硫胺素状态的关键变量。在4周的基线和6周的双盲治疗期间测量每周的饮食摄入量、主观感觉和活动评估。在每个周期的最后一周进行临床评估。为了进行治疗，受试者被随机分配到硫胺素(每天10毫克)或安慰剂组。与基线和安慰剂补充值相比，补充硫胺素的女性食欲、能量摄入量、体重和总体幸福感显著增加，疲劳感减少。补充硫胺素也倾向于减少白天的睡眠时间，改善睡眠模式，增加活动量。这些数据表明，当老年人出现厌食、体重减轻、疲劳、抑郁和睡眠障碍等非特异性疾病时，应评估硫胺素状态。
The effect of thiamin supplementation on the health and general well-being of 80 randomly selected healthy elderly Irish women, from a population with marginal thiamin deficiency, was studied. Key variables affecting thiamin status were controlled. Weekly dietary intakes, subjective feelings, and activity assessments were measured during a 4-week baseline and 6-week double blind treatment period. Clinical assessments were performed during the last week of each period. For treatment, subjects were randomly assigned to either thiamin (10 mg daily) or placebo groups. Compared to baseline and placebo supplemented values, thiamin-supplemented women experienced significantly increased appetite, energy intake, body weight and general well-being, and decreased fatigue. Thiamin supplementation also tended to reduce daytime sleep time, improve sleep patterns, and increase activity. These data suggest that evaluation of thiamin status is indicated when nonspecific conditions such as anorexia, weight loss, fatigue, depression, and sleep disorders are present in elderly persons.