Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application
Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application
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DOI：
10.1016/j.bioactmat.2018.12.001
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发表时间：
2019-12-01
影响因子：
18.9
通讯作者：
Liang, Luxin
中科院分区：
文献类型：
--
作者：
Ouyang, Sihui;Huang, Qianli;Liang, Luxin
本文采用放电等离子烧结（SPS）技术成功制备了Ti-Mg金属-金属复合材料（MMCs）。在体外研究了Ti-Mg金属-金属复合材料（MMCs）对SaOS-2细胞增殖和分化的影响。在体实验中，建立大鼠股骨髁部缺损模型，将钛镁复合材料植入股骨髁部。结果表明，Ti-Mg复合材料与SaOS-2细胞的细胞相容性较纯钛增强。显微计算机断层扫描（Micro-CT）结果显示，Ti-Mg种植体周围骨小梁体积明显多于Ti种植体周围，表明Ti-Mg MMCs种植体周围形成了更多活性新骨。苏木精-伊红（H&E）染色分析显示，钛-镁种植体周围的骨整合明显高于钛种植体周围。
In this work, Ti-Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti-Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti-Mg MMCs implants were embedded into the femur condyles. Results showed that Ti-Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti-Mg implants than around Ti implants, indicating that more active new-bone formed around Ti-Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti-Mg implants than that around Ti implants.