Palladium-Catalyzed Construction of Tetracyclic Scaffolds via the 1,7-Enyne Carbocyclization/Iodophenol Dearomatization Cascade
Palladium-Catalyzed Construction of Tetracyclic Scaffolds via the 1,7-Enyne Carbocyclization/Iodophenol Dearomatization Cascade
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钯催化通过 1,7-烯炔碳环化/碘苯酚脱芳构化级联构建四环支架
DOI：
10.1021/acs.joc.7b02196
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发表时间：
2017
影响因子：
3.6
通讯作者：
Liang Yong-Min
中科院分区：
文献类型：
--
作者：
Xia Yu;Wang Li-Jing;Wang Jia;Chen Si;Shen Yi;Guo Chun-Huan;Liang Yong-Min
已经开发出一种有效的钯催化的 1,7-烯炔与碘酚的脱芳构化 [2+2+1] 碳环化反应。该反应构建了一种四环支架，具有广泛的底物范围和中等至优异的产率。更重要的是，该方法为四环骨架天然产物的合成提供了潜在的策略。
An efficient palladium-catalyzed dearomatizing [2+2+1] carbocyclization of 1,7-enynes with iodophenols has been developed. A type of tetracyclic scaffold was built in this reaction, exhibiting a broad substrate scope with moderate to excellent yields. More importantly, this method provides a potential strategy for the synthesis of tetracyclic skeleton natural products.