The virulence of Streptococcus mutans and the ability to form biofilms.
The virulence of Streptococcus mutans and the ability to form biofilms.
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DOI：
10.1007/s10096-013-1993-7
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发表时间：
2014-04
影响因子：
4.5
通讯作者：
Skalniak, A.
中科院分区：
文献类型：
--
作者：
Krzysciak, W.;Jurczak, A.;Koscielniak, D.;Bystrowska, B.;Skalniak, A.
在某些疾病中，细菌形成多维复杂结构（称为生物膜）的能力发挥着非常重要的作用。口腔最常见的疾病，称为龋齿，是其中的佼佼者。变形链球菌是龋齿的众多病因之一，是一种能够获得新特性的微生物，能够表达致病性决定因素，决定其在特定环境条件下的毒力。通过粘附到固体表面的机制，变形链球菌能够在口腔中定植并形成细菌生物膜。使变形链球菌能够在口腔中定植的其他特性包括在酸性环境中生存的能力以及与定植在该生态系统中的其他微生物的特定相互作用。本综述试图确定哪些与生物膜形成相关的特征（变形链球菌的毒力决定因素）是导致龋齿发生的原因。为了扩展对链球菌感染性质的认识，将尝试解决以下问题： 生物膜形成是蛋白质与细菌相互作用的复杂过程。以变形链球菌为代表的致龋菌群微生物在毒力决定因素“表达”方面与生理菌群微生物有何不同？口腔环境及其微生物如何影响优势菌种生物膜的形成？选定的抑制剂如何影响致龋微生物的生物膜形成？
In some diseases, a very important role is played by the ability of bacteria to form multi-dimensional complex structure known as biofilm. The most common disease of the oral cavity, known as dental caries, is a top leader. Streptococcus mutans, one of the many etiological factors of dental caries, is a microorganism which is able to acquire new properties allowing for the expression of pathogenicity determinants determining its virulence in specific environmental conditions. Through the mechanism of adhesion to a solid surface, S. mutans is capable of colonizing the oral cavity and also of forming bacterial biofilm. Additional properties enabling S. mutans to colonize the oral cavity include the ability to survive in an acidic environment and specific interaction with other microorganisms colonizing this ecosystem. This review is an attempt to establish which characteristics associated with biofilm formation—virulence determinants of S. mutans—are responsible for the development of dental caries. In order to extend the knowledge of the nature of Streptococcus infections, an attempt to face the following problems will be made: Biofilm formation as a complex process of protein–bacterium interaction. To what extent do microorganisms of the cariogenic flora exemplified by S. mutans differ in virulence determinants “expression” from microorganisms of physiological flora? How does the environment of the oral cavity and its microorganisms affect the biofilm formation of dominant species? How do selected inhibitors affect the biofilm formation of cariogenic microorganisms?
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影响因子：
3.6
作者：
Brady LJ;Maddocks SE;Larson MR;Forsgren N;Persson K;Deivanayagam CC;Jenkinson HF
通讯作者：
Jenkinson HF
影响因子：
4.9
作者：
Anderson, Michele J.;Horn, Mary E.;Peterson, Marnie L.
通讯作者：
Peterson, Marnie L.
影响因子：
2.3
作者：
Edberg, Stephen C.
通讯作者：
Edberg, Stephen C.
影响因子：
7.6
作者：
GIBBONS, RJ;HAY, DI
通讯作者：
HAY, DI
影响因子：
3.1
作者：
Crowley, Paula J.;Seifert, Trevor B.;Brady, L. Jeannine
通讯作者：
Brady, L. Jeannine