LIPOSOMAL DELIVERY OF BIOLOGICAL RESPONSE MODIFIERS TO MACROPHAGES
LIPOSOMAL DELIVERY OF BIOLOGICAL RESPONSE MODIFIERS TO MACROPHAGES
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DOI：
10.1007/bf02175099
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
FIDLER, IJ
中科院分区：
文献类型：
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作者：
PAK, CC;FIDLER, IJ
被激活到杀瘤状态的巨噬细胞可以识别和摧毁肿瘤细胞，而不损害正常细胞。巨噬细胞的全身激活可以通过静脉注射含有各种免疫调节剂的脂质体来实现。就像任何颗粒一样，脂质体被吞噬细胞从循环中清除。这种被动但特异的免疫调节剂靶向巨噬细胞导致它们被激活，在体外和体内溶解肿瘤细胞，这可能对传统疗法具有抵抗力。
Macrophages activated to the tumoricidal state can recognize and destroy neoplastic cells and leave normal cells unharmed. Systemic activation of macrophages can be achieved by the intravenous administration of liposomes containing various immunomodulators. Much like any particle, liposomes are cleared from the circulation by phagocytic cells. This passive but specific targeting of immunomodulators to macrophages results in their activation for in vitro and in vivo lysis of tumor cells that can be resistant to conventional therapies.