Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.
Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.
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DOI：
10.1073/pnas.0308352100
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发表时间：
2004-02-03
影响因子：
11.1
通讯作者：
Osterhaus, ADME
中科院分区：
文献类型：
--
作者：
Fouchier, RAM;Schneeberger, PM;Osterhaus, ADME
H5亚型和H7亚型高致病性禽流感病毒是引起禽类鼠疫的病原。1997年和2003年，H5N1亚型甲型流感病毒也曾在香港造成人类严重呼吸道疾病，包括至少7例死亡病例，对人类大流行构成严重威胁。2003年2月底至5月底期间，荷兰爆发了一场家禽鼠疫。从鸡中分离到一株与野鸭低致病性禽流感病毒有密切关系的H7N7亚型高致病性禽流感病毒。随后，在86名接触受影响家禽的人及其三名家庭成员中检测到同样的病毒。在这89名患者中，78人表现为结膜炎，5人表现为结膜炎和流感样疾病，2人表现为流感样疾病，4人不符合病例定义。流感样疾病一般轻微，但也发生了肺炎合并急性呼吸窘迫综合征的致命病例。从人类获得的大多数病毒分离株，包括可能的第二例，都没有积累显著的突变。然而，从死亡病例中分离出的病毒显示出14个氨基酸替换，其中一些可能与该病例中的疾病增强有关。由于H7N7病毒过去曾多次在哺乳动物中引起疾病，包括马、海豹和人类，它们在人畜共患病潜力上可能是不寻常的，因此对人类构成大流行威胁。
Highly pathogenic avian influenza A viruses of subtypes H5 and H7 are the causative agents of fowl plague in poultry. Influenza A viruses of subtype H5N1 also caused severe respiratory disease in humans in Hong Kong in 1997 and 2003, including at least seven fatal cases, posing a serious human pandemic threat. Between the end of February and the end of May 2003, a fowl plague outbreak occurred in The Netherlands. A highly pathogenic avian influenza A virus of subtype H7N7, closely related to low pathogenic virus isolates obtained from wild ducks, was isolated from chickens. The same virus was detected subsequently in 86 humans who handled affected poultry and in three of their family members. Of these 89 patients, 78 presented with conjunctivitis, 5 presented with conjunctivitis and influenza-like illness, 2 presented with influenza-like illness, and 4 did not fit the case definitions. Influenza-like illnesses were generally mild, but a fatal case of pneumonia in combination with acute respiratory distress syndrome occurred also. Most virus isolates obtained from humans, including probable secondary cases, had not accumulated significant mutations. However, the virus isolated from the fatal case displayed 14 amino acid substitutions, some of which may be associated with enhanced disease in this case. Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans.