Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia
Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia
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DOI：
10.3109/14767058.2015.1032239
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发表时间：
2016-04-02
影响因子：
1.8
通讯作者：
Prusac, Ivana Kuzmic
中科院分区：
文献类型：
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作者：
Benzon, Sandra;Tomas, Sandra Zekic;Prusac, Ivana Kuzmic
目的：目的：比较不明原因绒毛炎（VUE）胎盘绒毛炎病灶中不同类型T淋巴细胞的免疫组化表达，探讨VUE合并子痫前期（PE）与VUE合并PE的差异。用CD 3、CD 4、FOXP 3、CD 25、CD 8和CD 68抗体对福尔马林固定和石蜡包埋的切片进行T淋巴细胞类型的免疫组化。结果：VUE合并PE患者胎盘组织中免疫组化CD 4 + T淋巴细胞计数及CD 4 +/CD 8+比值均高于对照组，结论：VUE合并PE患者胎盘组织中免疫组化CD 4 + T淋巴细胞计数及CD 4 +/CD 8+比值增高可能参与了PE的发病机制。
Objective: The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE).Methods: Fifty-four placentae were collected from women who had VUE with (N=27) and without (N=27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team.Results: There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group.Conclusion: The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.