Array of M protein gene subtypes in 1064 recent invasive group a streptococcus isolates recovered from the active bacterial core surveillance
Array of M protein gene subtypes in 1064 recent invasive group a streptococcus isolates recovered from the active bacterial core surveillance
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DOI：
10.1086/379050
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发表时间：
2003-11-15
影响因子：
6.4
通讯作者：
Beall, B
中科院分区：
文献类型：
--
作者：
Li, ZY;Sakota, V;Beall, B
利用序列分析检测高变M蛋白N末端的变异，我们在最近的多状态、基于群体的监测中连续分离的1064株侵袭性A组链球菌中发现了41种emm类型，包括81种亚型。由多个分离株代表的30种emm类型中，有17种显示出多个亚型。大多数亚型与参考菌株emm序列不同，这是由于单碱基替换或其他可能稳定遗传的改变。疾病控制和预防中心的数据库(可在http://。疾病预防控制中心。Gov / ncidod/ biotech/ strep/ strepblast。Htm)目前包含225种不同的emm类型，其中包含450个子类型。虽然这种亚型方案增加了特异性，但个体类型的有限变化有利于引入M蛋白型特异性疫苗。
Using sequence analysis to detect variation within the hypervariable M protein N terminus, we found 41 emm types encompassing 81 subtypes, among 1064 consecutive invasive group A streptococcus isolates from a recent multistate, population- based surveillance. Seventeen of the 30 emm types represented by multiple isolates displayed multiple subtypes. Most subtypes differed from reference strain emm sequences as a result of single base substitutions or other alterations likely to be stably inherited. The Centers for Disease Control and Prevention database ( available at: http:// www. cdc. gov/ ncidod/ biotech/ strep/ strepblast. htm) currently contains 225 distinct emm types encompassing 450 subtypes. Although this subtyping scheme increases specificity, limited variation within individual types favors introduction of M protein type - specific vaccines.