DOSE-EFFECT RELATIONSHIP OF DISULFIRAM IN HUMAN VOLUNTEERS .1. CLINICAL-STUDIES
DOSE-EFFECT RELATIONSHIP OF DISULFIRAM IN HUMAN VOLUNTEERS .1. CLINICAL-STUDIES
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DOI：
10.1111/j.1600-0773.1991.tb01215.x
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发表时间：
1991-03-01
期刊：
影响因子：
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通讯作者：
JOHANSSON, B
中科院分区：
文献类型：
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作者：
CHRISTENSEN, JK;MOLLER, IW;JOHANSSON, B
本研究的目的是研究Antabus（R）剂量与乙醇激发后双硫仑-乙醇反应（DAR）之间的关系。52名健康志愿者，29名男性和23名女性，年龄20-61岁，接受递增剂量的Antabuse（1，100，200，300 mg）治疗，每次14天。在每14天结束时，用0.15 g乙醇/kg体重挑战志愿者。在接下来的50分钟内监测血压、脉率、呼吸率和潮红、热感、恶心、呕吐、心悸、呼吸急促和头痛等症状。志愿者在经历有效DAR后离开研究。有效DAR主要根据患者的不适感定义，但出于安全性原因，也根据不可接受的循环变化定义，100 mg Antabuse后52名志愿者中有21名达到有效DAR，200 mg后27名，300 mg后4名。他们中的大多数人在脸红和循环系统发生变化后离开了研究，但并没有感到足够的不适来说服他们应该戒酒。因此，10名主观症状较弱但DAR有效的志愿者在下一次增加剂量后再次激发，并发生了稍微更强烈的反应。我们得出结论，每日剂量为200 mg的Antabuse在酒精存在下会引起志愿者的实质性反应。讨论了可能需要300 mg剂量的Antabuse来防止患者饮酒。
The aim of this study was to investigate the relation between Antabus(R) dosage and the disulfiram-alcohol reaction (DAR) after ethanol challenge. Fifty-two healthy volunteers, 29 men and 23 women, aged 20-61 years, were treated with increasing doses of Antabuse (1, 100, 200, 300 mg) for 14 days each. At the end of each 14 days the volunteers were challenged with 0.15 g ethanol/kg body weight. Blood pressure, pulse rate, respiration rate, and symptoms such as flushing, heat sensation, nausea, vomiting, palpitations, breathlessness, and headache were monitored for the next 50 min. The volunteers left the study when they had experienced a valid DAR. A valid DAR, which was principally defined on the basis of the patients' feeling of discomfort, but for safety reasons also on the basis of unacceptable circulatory changes, was reached in 21 out of 52 volunteers after 100 mg Antabuse, in 27 after 200 mg, and in 4 after 300 mg. Most of them left the study after flushing and circulatory changes, but did not feel ill enough to be convinced that they should abstain from drinking. Ten volunteers with weak subjective symptoms, but with a valid DAR, were therefore rechallenged after the next increased dose and experienced a somewhat stronger reaction. We conclude that a daily dose of 200 mg Antabuse brings about a substantial reaction in volunteers in the presence of alcohol. The possible need for a 300 mg dose of Antabuse to prevent a patient from drinking was discussed.