Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.

Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.
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DOI:
10.1088/1361-6579/aa60b7
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发表时间:
2017-04
影响因子:
3.2
通讯作者:
Yu G
Yu G
中科院分区:
工程技术3区
文献类型:
--
作者:
Shang Y;Li T;Yu G

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血流是一种这样的可用的可观察量,其单独地以及与其他度量组合地促进了大量的生理洞察。近红外漫相关光谱(DCS),并在较小程度上,扩散相关断层扫描(DCT),越来越受到关注,在过去的十年中,作为非侵入性的组织血流测量和成像方法。DCS/DCT为组织血流测量/成像提供了几个有吸引力的功能,例如无创性、便携性、高时间分辨率和相对较大的穿透深度(高达几厘米)。本文首先介绍DCS/DCT的基本原理和仪器,然后介绍DCS/DCT在包括脑、骨骼肌和肿瘤在内的多种器官/组织疾病的诊断和治疗监测中的临床应用实例。临床研究结果证明DCS/DCT在为疾病诊断和干预监测提供重要信息方面的技术多功能性。
Blood flow is one such available observable promoting a wealth of physiological insight both individually and in combination with other metrics. Near-infrared diffuse correlation spectroscopy (DCS) and, to a lesser extent, diffuse correlation tomography (DCT), have increasingly received interest over the past decade as noninvasive methods for tissue blood flow measurements and imaging. DCS/DCT offers several attractive features for tissue blood flow measurements/imaging such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth (up to several centimeters). This review first introduces the basic principle and instrumentation of DCS/DCT, followed by presenting clinical application examples of DCS/DCT for the diagnosis and therapeutic monitoring of diseases in a variety of organs/tissues including brain, skeletal muscle, and tumor. Clinical study results demonstrate technical versatility of DCS/DCT in providing important information for disease diagnosis and intervention monitoring.
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