THE BASALIS OF THE PRIMATE ENDOMETRIUM - A BIFUNCTIONAL GERMINAL COMPARTMENT
THE BASALIS OF THE PRIMATE ENDOMETRIUM - A BIFUNCTIONAL GERMINAL COMPARTMENT
复制标题
DOI：
10.1095/biolreprod40.3.681
复制
发表时间：
1989-03-01
影响因子：
3.6
通讯作者：
KAISERMANABRAMOF, IR
中科院分区：
文献类型：
--
作者：
PADYKULA, HA;COLES, LG;KAISERMANABRAMOF, IR
放射自显影分析的上皮细胞和基质细胞增殖的灵长类动物子宫内膜functionalis和basalis（恒河猴）已确定水平带状模式的有丝分裂激活和抑制在自然月经周期。在单次静脉注射[3H]胸苷后1 h，在从晚期增殖期到晚期黄体期的9天（相对于雌激素[E2]峰值为-2天至+14天）测定子宫内膜活检（子宫切开术）中的有丝分裂活性。在4个水平子宫内膜区的腺体段内测定标记指数（LI）：暂时功能区I（腔上皮）和区II（最上腺体）;基底Germinalis：区III（中腺体）和区IV（基底腺体）。分裂上皮细胞群（LI）的大小不同地带。在E2优势期（-2天至+3天），功能性I（10. ±. 0.3%）和II（9.8 ±. 1.0%）高于基底细胞III（5.8 ± 1.0%）。0.2%）和基底IV（3.7. ±. 0.8%）。在孕酮（P）优势期（+5天至+14天），功能性I（4.3.+-. 1.9%），功能性II（0.8 ±. 0.2%）和基底细胞III（1.4. ±. 0.5%）。因此，gerrybasalis III与瞬时functionalis I和II的排卵期上皮细胞增殖和排卵后有丝分裂抑制的均匀性功能。独特的有丝分裂模式使基底IV区与其他区分开，LI从1%（-2天）稳步上升至11%（+10天）。基质成纤维细胞的LI在基底IV中保持相当均匀，但在其他区域中变化。因此，排卵后的灵长类基底是一个独特的二分室，其中基底IV腺上皮的有丝分裂率稳步上升，而基底III的强烈抑制。基底层IV上皮细胞有丝分裂活性的显著增强可能反映了妊娠期生长或月经后再生的干祖细胞群的扩增。
Radioautographic analysis of epithelial and stromal cell proliferation in the primate endometrial functionalis and basalis (rhesus monkey) has identified horizontal zonal patterns of mitotic activation and inhibition during natural menstrual cycles. At 1 h after a single i.v. injection of [3H]thymidine, mitotic activity in endometrial biopsies (hysterotomy) was determined on 9 days from the late proliferative to the late luteal phase (-2 days to +14 days relative to the estrogen [E2] peak). Labeling indices (LIs) were determined within glandular segments of the 4 horizontal endometrial zones: Transient functionalias Zone I (luminal epithelium) and Zone II (uppermost gland); Germinal basalis: Zone III (middle gland) and Zone IV (basal gland). The size of the dividing epithelial populations (LI) differed zonally. During E2 dominance (-2 days to +3 days), the epithelial LIs of functionalis I (10 .+-. 0.3%) and II (9.8 .+-. 1.0%) were greater than those of basalis III (5.8 .+-. 0.2%) and basalis IV (3.7 .+-. 0.8%). During progesterone (P) dominance (+5 days to +14 days), epithelial mitosis was strongly inhibited in functionalis I (4.3 .+-. 1.9%), functionalis II (0.8 .+-. 0.2%), and basalis III (1.4 .+-. 0.5%). Thus germinal basalis III was linked functionally with transient functionalis I and II by periovulatory uniformity in epithelial proliferation and postovulatory mitotic inhibition. A unique mitotic pattern set basalis IV apart from other zones by a steady rise in LI from 1 % (-2 days ) to 11% (+10 days). The LIs for stromal fibroblasts remained quite uniform in basalis IV but varied in other zones. Thus the postovulatory primate basalis was a distinct bipartite compartment in which the mitotic rate in basalis IV glandular epithelium increased steadily whereas that of basalis III was strongly inhibited. The remarkable enhancement of epithelial mitotic activity in basalis IV may reflect expansion of the stem-progenitor cell population for gestational growth or for post-menstrual regeneration.