One-pot method for α-phenylation of ketones using isoxazolidine and triphenylaluminum
One-pot method for α-phenylation of ketones using isoxazolidine and triphenylaluminum
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DOI：
10.1016/j.tetlet.2012.05.146
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发表时间：
2012-08-08
影响因子：
1.8
通讯作者：
Miyata, Okiko
中科院分区：
文献类型：
--
作者：
Miyoshi, Tetsuya;Sato, Shohei;Miyata, Okiko
本文报道了一锅法通过N-烯基异恶唑烷对酮进行α-苯基化反应。在异恶唑烷存在下，用由苯基氯化镁和AlCl 3制备的三苯基铝处理各种酮时，以良好至中等产率获得所需产物。该方法相当于羰基的直接α-芳基化反应。(C)2012爱思唯尔有限公司保留所有权利。
The efficient one-pot umpolung alpha-phenylation of ketones via N-alkenylisoxazolidine is described. When the various ketones are treated with triphenylaluminum prepared from phenylmagnesium chloride and AlCl3 in the presence of isoxazolidine, the desired products are obtained in good to moderate yield. This method is equivalent to a direct alpha-arylation reaction of carbonyl groups. (C) 2012 Elsevier Ltd. All rights reserved.