The effect of low-dose ritonavir monotherapy on fasting serum lipid concentrations
The effect of low-dose ritonavir monotherapy on fasting serum lipid concentrations
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DOI：
10.1111/j.1468-1293.2005.00328.x
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发表时间：
2005-11-01
期刊：
影响因子：
3
通讯作者：
Roberts, SE
中科院分区：
文献类型：
--
作者：
Shafran, SD;Mashinter, LD;Roberts, SE
目的利托那韦（RTV）400 mg每日2次（bid）或更高剂量对血脂有不良影响。然而，RTV 100 mg bid对血脂的影响尚不清楚。我们进行了一项研究，以评估RTV 100 mg bid对空腹血脂谱在HIV阴性的健康volunteers.Methods利托那韦100 mg bid的效果，给药14天，20名健康的HIV血清阴性成人正常血脂。7天洗脱期后，给予洛匹那韦/利托那韦（LPV/RTV）400/ 100 mg bid，持续14天。在基线、RTV 14天后和LPV/RTV 14天后测量两次空腹血脂参数，并在每个时间点对总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、总/HDL胆固醇比值和甘油三酯水平进行比较。总胆固醇水平上升10.2% LDL胆固醇水平升高16.2%（P < 0.001）（P < 0.001），甘油三酯升高26.5%高密度脂蛋白胆固醇水平降低5.4%（P <0.001），总胆固醇/高密度脂蛋白胆固醇比值升高17.3%（P < 0.001）。在RTV 100 mg bid基础上添加LPV 400 mg bid，LDL胆固醇或甘油三酯水平或总/HDL胆固醇比值未发生显著进一步变化，但总胆固醇和甘油三酯水平均显著升高。（增加8.0%; P = 0.007）和HDL胆固醇水平（上升6.7%;结论利托那韦100 mg bid可显著增加总胆固醇、LDL胆固醇、总/HDL胆固醇比率和甘油三酯以及降低的HDL胆固醇浓度。在RTV 100 mg bid基础上添加LPV 400 mg bid进一步增加了总胆固醇和HDL胆固醇水平，而不影响总/HDL比值。
Objectives Ritonavir (RTV) at doses of 400 mg twice a day (bid) or higher adversely affects serum lipids. However, the effect of RTV 100 mg bid on serum lipids is unknown. We conducted a study to evaluate the effect of RTV 100 mg bid on fasting serum lipid profiles in HIV-negative healthy volunteers.Methods Ritonavir 100 mg bid was administered for 14 days to 20 healthy HIV-seronegative adults with normal serum lipids. After a 7-day washout, lopinavir/ritonavir (LPV/RTV) 400/ 100 mg bid was administered for 14 days. Fasting serum lipid parameters were measured twice at baseline, after 14 days of RTV, and after 14 days of LPV/RTV, and comparisons were made at each time-point for levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, the total/HDL cholesterol ratio and triglycerides.Results After 14 days of RTV 100 mg bid, total cholesterol level increased by 10.2% (P < 0.001), LDL cholesterol level increased by 16.2% (P < 0.001), triglyceride levels increased by 26.5% (P < 0.001), HDL cholesterol level decreased by 5.4% (P < 0.01) and the total/HDL cholesterol ratio increased by 17.3% (P < 0.001). The addition of LPV 400 mg bid to RTV 100 mg bid resulted in no significant further changes in LDL cholesterol or triglyceride level or total/HDL cholesterol ratio, but there were significant increases in both total cholesterol (8.0% increase; P = 0.007) and HDL cholesterol levels (6.7% increase; P = 0.008).Conclusions Ritonavir dosed at 100 mg bid significantly increased the concentration of total cholesterol, LDL cholesterol, total/HDL cholesterol ratio and triglycerides and reduced HDL cholesterol concentration. The addition of LPV 400 mg bid to RTV 100 mg bid further increased both total and HDL cholesterol levels without affecting the total/HDL ratio.