Sex-dependent age modulation of frontostriatal and temporo-parietal activation during cognitive control
Sex-dependent age modulation of frontostriatal and temporo-parietal activation during cognitive control
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DOI：
10.1016/j.neuroimage.2009.06.070
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发表时间：
2009-10-15
期刊：
影响因子：
5.7
通讯作者：
Rubia, Katya
中科院分区：
文献类型：
--
作者：
Christakou, Anastasia;Halari, Rozmin;Rubia, Katya
认知控制的发育功能成像研究表明，在男性从童年到成年的发育过程中，与任务相关的前额纹状体激活随着年龄的增长而逐渐增加。然而，关于性别是如何影响这种功能发育的，人们知之甚少。在这项研究中，我们使用事件相关功能磁共振成像技术，在63名13至38岁的男女青少年和成年人中，考察了性别、年龄及其交互作用对注意转换和干扰抑制过程中脑激活的影响。在任务特定的额叶、纹状体和顶叶激活中，观察到所有受试者的线性年龄相关性。性别分析显示，在转换任务中，女性前额纹状体区域的激活高于男性，在Simon任务中，女性表现出偏侧效应，女性表现出左侧下前额叶和颞叶激活的增加，男性表现出右侧前额下部和顶叶激活的增加。女性增加的前额叶激活簇和男性增加的顶叶激活簇进一步与整个组中与年龄相关的簇重叠，潜在地反映了女性更成熟的前额叶脑激活模式和男性更成熟的顶叶激活模式。性别和年龄的交互作用进一步支持了这种分离，在两个任务中，在下部和内侧前额叶脑区显示了女性特有的年龄相关性，在顶上(Switch任务)和颞区(Simon任务)显示了男性特有的年龄相关性。这些发现表明，在认知控制任务中，女性与年龄相关的前额叶激活和男性与年龄相关的顶叶激活的招募增加。因此，额叶和顶叶招募的性别差异可能与这些脑区神经功能成熟的性别差异有关。(C)2009 Elsevier Inc.保留所有权利。
Developmental functional imaging Studies of cognitive control show progressive age-related increase in task-relevant fronto-striatal activation in male development from childhood to adulthood. Little is known, however, about how gender affects this functional development. In this study, we used event related functional magnetic resonance imaging to examine effects of sex, age, and their interaction on brain activation during attentional switching and interference inhibition, in 63 male and female adolescents and adults, aged 13 to 38. Linear age correlations were observed across all subjects in task-specific frontal, striatal and temporo-parietal activation. Gender analysis revealed increased activation in females relative to males in fronto-striatal areas during the Switch task, and laterality effects in the Simon task, with females showing increased left inferior prefrontal and temporal activation, and males showing increased right inferior prefrontal and parietal activation. Increased prefrontal activation clusters in females and increased parietal activation clusters in males furthermore overlapped with clusters that were age-correlated across the whole group, potentially reflecting more mature prefrontal brain activation patterns for females, and more mature parietal activation patterns for males. Gender by age interactions further supported this dissociation, revealing exclusive female-specific age correlations in inferior and medial prefrontal brain regions during both tasks, and exclusive male-specific age correlations in superior parietal (Switch task) and temporal regions (Simon task). These findings show increased recruitment of age-correlated prefrontal activation in females, and of age-correlated parietal activation in males, during tasks of cognitive control. Gender differences in frontal and parietal recruitment may thus be related to gender differences in the neurofunctional Maturation of these brain regions. (C) 2009 Elsevier Inc. All rights reserved.