Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand's disease.
Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand's disease.
复制标题
储存池疾病和摄入阿司匹林后血小板与内皮下层的相互作用（粘附聚集）受损。
DOI：
10.1056/nejm197509252931301
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Baumgartner
中科院分区：
文献类型：
--
作者：
H. Weiss;T. Tschopp;H. Baumgartner
血小板与内皮下表面的相互作用中可能存在的缺陷进行了评估，在6例储存池病，9例血管性血友病和7例正常人谁摄入阿司匹林。柠檬酸盐血液灌注通过一个含有外翻的兔主动脉节段的腔室，该节段先前通过球囊导管剥脱内皮。正常血液，83.3 +/-1.9%（S.E.M.）的表面被粘附的血小板覆盖。服用阿司匹林后血小板粘附正常（89.7 +/-4.6%），并且在一些储存池病患者中降低。这两种情况下最显著的缺陷是几乎没有血小板血栓。相比之下，粘连减少（57.3 +/-3.4%），但血栓形成正常，是von Willebrand病的特征。这些类型的血小板粘附和聚集缺陷可能是各种出血性疾病中止血缺陷的原因。研究结果进一步表明阿司匹林作为一种抗血栓药物可能有用。
Possible defects in the interaction of platelets with the subendothelial surface were evaluated in six patients with storeage-pool disease, nine patients with von Willebrand's disease and seven normal subjects who ingested aspirin. Citrated blood was perfused through a chamber containing everted segments of rabbit aorta previously denuded of endothelium by means of a ballon catheter. With normal blood, 83.3 +/- 1.9 per cent (S.E.M.) of the surface was covered by adherent platelets. Platelet adhesion was normal after aspirin ingestion (89.7 +/- 4.6 per cent) and decreased in some patients with storage-pool disease. The most striking defect in both circumstances was the virtual absence of platelet thrombi. In contrast, decreased adhesion (57.3 +/- 3.4 per cent), but normal thrombus formation, was characteristic of von Willebrand's disease. These types of defects in platelet adhesion and aggregation may account for the hemostatic defects in a variety of bleeding disorders. The findings further suggest the possible usefulness of aspirin as an antithrombotic agent.