Immunotherapy of melanoma with BCG: Two fatalities following intralesional injection

Immunotherapy of melanoma with BCG: Two fatalities following intralesional injection
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卡介苗黑色素瘤免疫治疗：病灶内注射导致两人死亡

DOI：
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发表时间：
1975
期刊：
Cancer
影响因子：
6.2
通讯作者：
MD Charles F. McKhann
MD Charles F. McKhann
中科院分区：
医学1区
文献类型：
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作者：
MD CHARLES F. MCKHARN;MD CHARLES G. HENDRICKSON;MD LYNN E. SPITLER;MD AUDOLFUR GUNNARSSON;M. D. D. BANERJEE;MD WILLIAM R. NELSON;MD Charles F. McKhann

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据报道，在瘤内注射卡介苗用于恶性黑色素瘤的免疫治疗后，有两例死亡病例。在这两个病例中，终末事件的特征是高热、主要凝血缺陷、低血压和无尿，这表明其机制是对卡介苗的过敏。
Two fatalities are reported following intralesional injection of BCG for immuno‐therapy of malignant melanoma. In both cases the terminal events were characterized by high fevers, major clotting defects, hypotension, and anuria, suggesting that the mechanism was hypersensitivity to BCG.