ARE BINGE DRINKERS MORE AT RISK OF DEVELOPING BRAIN-DAMAGE
ARE BINGE DRINKERS MORE AT RISK OF DEVELOPING BRAIN-DAMAGE
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DOI：
10.1016/0741-8329(93)90083-z
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发表时间：
1993-11-01
期刊：
影响因子：
2.3
通讯作者：
HUNT, WA
中科院分区：
文献类型：
--
作者：
HUNT, WA
酗酒通常与脑损伤和认知缺陷有关。由于饮酒模式可能包括饮酒后禁酒，因此酗酒可能会增加大脑损伤的可能性。长期服用乙醇会导致 N-甲基-D-天冬氨酸 (NMDA) 和钙受体上调，并增加糖皮质激素的释放。 NMDA 介导的机制和糖皮质激素对海马的作用与脑损伤有关。因此，乙醇戒断可能会使大脑更容易受到这些机制的损害，尤其是在酗酒时。用于治疗乙醇戒断的治疗辅助剂，包括 NMDA、钙和糖皮质激素拮抗剂，最终可能有助于预防酒精中毒引起的进一步脑损伤。
Alcoholism is often associated with brain damage and cognitive deficits. Because drinking patterns can include periods of alcohol consumption followed by abstinence, binge drinking may enhance the possibility of brain damage. Chronic administration of ethanol leads to upregulation of N-methyl-D-aspartate (NMDA) and calcium receptors and increased release of glucocorticoids. NMDA-mediated mechanisms and glucocorticoid actions on the hippocampus are associated with brain damage. Thus, ethanol withdrawal may make the brain more vulnerable to damage from these mechanisms, especially with binge drinking. Therapeutic adjuncts for treating ethanol withdrawal, including NMDA, calcium, and glucocorticoid antagonists, may eventually prove useful in preventing further brain damage in alcoholism.