Anxiolytic-like effect of linezolid in experimental mouse models of anxiety
Anxiolytic-like effect of linezolid in experimental mouse models of anxiety
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DOI：
10.1016/j.pnpbp.2012.09.006
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发表时间：
2013-01-10
影响因子：
5.6
通讯作者：
Kumar, Baldev
中科院分区：
文献类型：
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作者：
Jindal, Ankur;Mahesh, Radhakrishnan;Kumar, Baldev
利奈唑胺是一种恶唑烷酮类抗生素，是单胺氧化酶（MAO）的可逆性非选择性抑制剂，主要针对MAO - A亚型。其抗抑郁样作用先前已在啮齿动物抑郁模型中得到证实。MAO - A酶已被证明在焦虑症的病理生理学中起作用，大脑中MAO - A的抑制可用于治疗焦虑症。因此，本研究的目的是探讨利奈唑胺在啮齿动物焦虑模型中的假定抗焦虑作用。小鼠被急性注射利奈唑胺（5 - 40 mg/kg，腹腔注射）、地西泮（2 mg/kg，腹腔注射）和吗氯贝胺（10 mg/kg，腹腔注射）。利奈唑胺（20和40 mg/kg）、地西泮和吗氯贝胺显著（p<...此处原文似乎不完整）
Linezolid, an oxazolidinone class antibiotic is a reversible and nonselective inhibitor of monoamine oxidase (MAO) enzyme, mainly for MAO-A subtype. Its antidepressant-like effect has been previously demonstrated in the rodent models of depression. MAO-A enzyme has been shown to play a role in the pathophysiology of anxiety disorders and inhibition of MAO-A in the brain could be used to treat anxiety disorders. Thus, the objective of this study was to investigate the putative anxiolytic effects of linezolid in rodent models of anxiety. Mice were acutely injected with linezolid (5-40 mg/kg, i.p.), diazepam (2 mg/kg, i.p.) and moclobemide (10 mg/kg., i.p.). Linezolid (20 and 40 mg/kg), diazepam and moclobemide significantly (p