Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia: similarities and differences compared to adults.
Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia: similarities and differences compared to adults.
复制标题
急性非淋巴细胞白血病儿童预后与骨髓染色体模式的相关性：与成人相比的异同。
作者：
William F. Benedict;Marilyn Lange;Julie Greene;Anna Derencsenyi;Omar S. Alfi
本文对28例诊断为急性非淋巴细胞白血病（ANLL）的患儿进行了染色体补体检查。在这些患者中发现50%的异常细胞遗传学模式，这与成人ANLL的结果相似。然而，与成人患者的报告不同，未发现特异性染色体改变，这一观察结果可能意味着ANLL中异常克隆形成的病因和机制在儿童和成人之间可能存在显着差异。在初始骨髓样本中染色体异常的患者的中位生存期为7.1个月，而在骨髓中二倍体模式正常的患者的中位生存期为20.5个月（单侧，p = 0.04）。如果所有中期细胞均异常，中位生存期仅为3个月。
The chromosomal complement of 28 children with the diagnosis of acute nonlymphocytic leukemia (ANLL) were examined. An abnormal cytogenetic pattern was found in 50% of these patients, which is similar to the results in adults with ANLL. Unlike the reports in adult patients, however, no specific chromosomal changes were found. This observation may imply that the etiology and mechanisms by which abnormal clones develop in ANLL could differ significantly between children and adults. Those patients with chromosomal abnormalities in their initial bone marrow sample had a median survival of 7.1 mo, whereas those with a normal diploid pattern in their bone marrow had a median survival of 20.5 mo (1-sided, p = 0.04). If all metaphases were abnormal, the median survival was only 3 mo.