Thy-1 expression during 3T3-L1 adipogenesis
Thy-1 expression during 3T3-L1 adipogenesis
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DOI：
10.1055/s-2004-826023
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发表时间：
2004-10-01
影响因子：
2.2
通讯作者：
Sorisky, A
中科院分区：
文献类型：
--
作者：
Gagnon, A;Chaar, J;Sorisky, A
Thy-1（也称为CD 90）是属于免疫球蛋白超家族的小糖蛋白[1]。它通过糖基磷脂酰肌醇连接定位于质膜内的脂筏微区。在小鼠中，Thy-1主要在T细胞、胸腺细胞、神经元和骨髓源性干细胞中表达[1，2]。虽然对Thy-1分子的结构特性了解很多，但对其功能知之甚少。Thy-1缺失的小鼠仅具有细微的表型，包括长时程增强中的神经元缺陷以及增强的T细胞抗原受体功能[3，4]。人Thy-1分子已被鉴定为内皮细胞中的炎症依赖性粘附分子，其中其介导与单核细胞、粒细胞和黑素瘤细胞的相互作用[5，6]。在使用小鼠胸腺瘤细胞的研究中也提出了粘附作用，其中报告了它们以Thy-1依赖性方式结合星形胶质细胞[7]。已在人类卵巢细胞中检测到Thy-1，并且在人类卵巢癌中观察到Thy-1表达的功能性破坏[8]。
Thy-1 (also known as CD90) is a small glycoprotein belonging to the immunoglobulin superfamily [1]. It is localized to lipid raft microdomains within the plasma membrane by virtue of a glycosyl phosphatidylinositol linkage. In mice, Thy-1 is predominantly expressed in T cells, thymocytes, neurons and bone marrow-derived stem cells [1, 2]. Although much is known about the structural properties of the Thy-1 molecule, very little is known about its function. Mice null for Thy-1 have only a subtle phenotype, including a neuronal defect in long-term potentiation, as well as enhanced T cell antigen receptor function [3, 4].The human Thy-1 molecule has been identified as an inflammation-dependent adhesion molecule in endothelial cells, where it mediates interactions with monocytes, granulocytes, and melanoma cells [5, 6]. A role in adhesion was also suggested in studies using murine thymoma cells, in which they were reported to bind astrocytes in a Thy-1-dependent manner [7]. Thy-1 has been detected in human ovarian cells, and functional disruption of Thy-1 expression was noted in human ovarian cancer [8].