The Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts
The Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts
复制标题
DOI：
10.1093/cercor/bhn021
复制
发表时间：
2008-11-01
期刊：
影响因子：
3.7
通讯作者：
Mesulam, M. Marsel
中科院分区：
文献类型：
--
作者：
Mohanty, Aprajita;Gitelman, Darren R.;Mesulam, M. Marsel
人脑如何根据动机需要整合多域信息来引导空间注意？为了解决这个问题，我们在一个新的隐蔽空间注意范式中测量了对预测外围注意目标（食物或工具图像）位置的中央线索的血流动力学反应。食物相关注意目标的动机相关性通过饥饿和饱腹感被实验操纵。杏仁核、后扣带、蓝斑和黑质在饥饿时表现出对食物相关线索的选择性敏感性，而在饱足时则没有，这种效应并不适用于工具。后顶叶皮层（PPC），包括顶叶内沟、后扣带回和眼窝额叶皮层，不仅对动机状态敏感，而且对目标的动机值敏感，与注意力转移速度相关。注意偏向与动机相关的食物目标时，PPC和后扣带之间的功能耦合更强。这些结果揭示了空间注意中动机显著性的联合边缘和单胺能编码。他们强调后顶叶和扣带皮层在整合动机信息和空间注意方面的交互作用，这一过程对于在目标位置和相关性快速变化的环境中选择性分配注意资源至关重要。
How does the human brain integrate information from multiple domains to guide spatial attention according to motivational needs? To address this question, we measured hemodynamic responses to central cues predicting locations of peripheral attentional targets (food or tool images) in a novel covert spatial attention paradigm. The motivational relevance of food-related attentional targets was experimentally manipulated via hunger and satiety. Amygdala, posterior cingulate, locus coeruleus, and substantia nigra showed selective sensitivity to food-related cues when hungry but not when satiated, an effect that did not generalize to tools. Posterior parietal cortex (PPC), including intraparietal sulcus, posterior cingulate, and the orbitofrontal cortex displayed correlations with the speed of attentional shifts that were sensitive not just to motivational state but also to the motivational value of the target. Stronger functional coupling between PPC and posterior cingulate occurred during attentional biasing toward motivationally relevant food targets. These results reveal conjoint limbic and monoaminergic encoding of motivational salience in spatial attention. They emphasize the interactive role of posterior parietal and cingulate cortices in integrating motivational information with spatial attention, a process that is critical for selective allocation of attentional resources in an environment where target position and relevance can change rapidly.