Gastric carcinoma with lymphoid stroma -: Incidence of EBV and Helicobacter pylori infection
Gastric carcinoma with lymphoid stroma -: Incidence of EBV and Helicobacter pylori infection
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DOI：
10.1097/00129039-200306000-00010
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发表时间：
2003-06-01
影响因子：
1.6
通讯作者：
Lee, SS
中科院分区：
文献类型：
--
作者：
Cho, HJ;Kim, JY;Lee, SS
据报道，胃淋巴上皮瘤样癌 (LELC) 与 Epstein-Barr 病毒 (EBV) 有关，并且比典型的腺癌具有更好的预后。然而，EBV 的发病率及其与幽门螺杆菌的关系存在争议。在我们的系列研究中，370 例胃腺癌中有 9 例 (2.4%) 为 LELC。用抗 CD3、CD20 和 Ki-67 的单克隆抗体对福尔马林固定、石蜡包埋的 LELC 组织进行免疫染色。对幽门螺杆菌进行 Warthin-Starry 染色，并对 EBV 进行原位杂交。作为对照，21 例淋巴间质突出的腺癌与 LELC 进行比较。 LELC 最常见的部位是胃体（5 例），其次是贲门（2 例），而胃窦是对照组最常见的部位。 LELC 组和对照组之间的年龄、性别或淋巴结转移情况没有显着差异。平均 Ki-67 指数相似（LELC 为 38.2%，对照为 35.3%）。 2 例 LELC 病例（22%）和 6 例对照病例（28.5%）中发现幽门螺杆菌。 7 例 LELC 病例（77.8%）和 4 例对照病例（19.0%）EBV 呈阳性。所有 LELC 患者均存活且状况良好，而对照组中有 3 名患者死于该病。尽管 EBV 似乎是一个促成因素，但幽门螺杆菌在 LELC 中的作用较小。除了肿瘤位于胃体的位置以及 LELC 预后较好的趋势之外，LELC 与对照组之间没有临床病理学差异。
Lymphoepithelioma-like carcinoma (LELC) of the stomach is reported to be associated with Epstein-Barr virus (EBV) and to have a better prognosis than typical adenocarcinoma. However, the incidence of EBV and its association with Helicobacter pylori is controversial. In our series, 9 of 370 (2.4%) cases of gastric adenocarcinoma were LELC. Formalin-fixed, paraffin-embedded LELC tissue was immunostained with monoclonal antibodies against CD3, CD20, and Ki-67. Warthin-Starry stain for H. pylori and in situ hybridization for EBV were performed. As a control, 21 cases of adenocarcinoma with prominent lymphoid stroma were compared with LELC. The most common location of LELC was the body of the stomach (five cases), followed by the cardia (two cases), whereas the antrum was the most common site for the control group. There were no significant differences in age, sex, or lymph node metastasis between the LELC and control groups. The mean Ki-67 index was similar (38.2% in LELC versus 35.3% in control). H. pylori was found in 2 LELC cases (22%) and 6 controls (28.5%). EBV was positive in 7 LELC cases (77.8%) and 4 controls (19.0%). All patients with LELC are alive and well, whereas three patients have died of their disease in the control group. Although EBV appeared to be a contributing factor, H. pylori had a minor role in LELC. There were no clinicopathologic differences between LELC and the control group, except for the location of the tumor in the body of the stomach and the tendency toward a better prognosis in LELC.