Parietofrontal network upregulation after motor stroke
Parietofrontal network upregulation after motor stroke
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DOI：
10.1016/j.nicl.2018.03.006
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发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Gerloff, C.
中科院分区：
文献类型：
--
作者：
Boenstrup, M.;Schulz, R.;Gerloff, C.
目的：脑卒中后运动功能的恢复具有较高的个体间差异性。大脑形成新连接的潜力决定了运动功能恢复的个体水平。我们的大多数日常活动都需要视觉整合，这涉及顶叶区域。与额叶运动系统相比，对顶叶运动系统与中风恢复相关的重构知之甚少。在这里，我们测试了顶叶和额叶运动区之间的功能连接是否在中风后经历了可塑性变化，并评估了中风后运动功能的行为相关性。我们通过测量高密度脑电图（EEG）和评估任务，研究了卒中损伤引起的功能连接的变化。在视觉引导的抓握任务与麻痹的手在30例慢性中风患者的可变运动缺陷和19名健康对照组的相关变化。定量变化的任务相关的连贯性在感觉运动的节奏进行了比较，剩余的电机defictions.Results：顶叶额叶耦合显着较强的患者相比，对照组。而运动网络耦合在两组的任务普遍增加，任务相关的一致性顶叶和初级运动皮层之间的中风损伤的半球显示出增加连接在广泛的感觉运动节奏。特别是顶叶额叶任务引起的耦合模式是显着的，正相关的九孔钉测试性能和gripleforce.Interpretation的残留损害：这些结果表明，顶叶额叶运动系统的整合在视觉引导的运动是更强的中风病变的大脑。与残余运动缺陷的相关性可能表明运动网络损伤的非特异性标志物，或者可能表明上调的顶额叶连接对卒中后运动功能有一定影响。
Objective: Motor recovery after stroke shows a high inter-subject variability. The brain's potential to form new connections determines individual levels of recovery of motor function. Most of our daily activities require visuomotor integration, which engages parietal areas. Compared to the frontal motor system, less is known about the parietal motor system's reconfiguration related to stroke recovery. Here, we tested if functional connectivity among parietal and frontal motor areas undergoes plastic changes after stroke and assessed the behavioral relevance for motor function after stroke.Methods: We investigated stroke lesion-induced changes in functional connectivity by measuring high-density electroencephalography (EEG) and assessing task-related changes in coherence during a visually guided grip task with the paretic hand in 30 chronic stroke patients with variable motor deficits and 19 healthy control subjects. Quantitative changes in task-related coherence in sensorimotor rhythms were compared to the residual motor deficit.Results: Parietofrontal coupling was significantly stronger in patients compared to controls. Whereas motor network coupling generally increased during the task in both groups, the task-related coherence between the parietal and primary motor cortex in the stroke lesioned hemisphere showed increased connectivity across a broad range of sensorimotor rhythms. Particularly the parietofrontal task-induced coupling pattern was significantly and positively related to residual impairment in the Nine-Hole Peg Test performance and grip force.Interpretation: These results demonstrate that parietofrontal motor system integration during visually guided movements is stronger in the stroke-lesioned brain. The correlation with the residual motor deficit could either indicate an unspecific marker of motor network damage or it might indicate that upregulated parietofrontal connectivity has some impact on post-stroke motor function.