Replantation of permanent incisors in children using Emdogain®
Replantation of permanent incisors in children using Emdogain®
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DOI：
10.1111/j.1600-9657.2005.00316.x
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发表时间：
2005-10-01
影响因子：
2.5
通讯作者：
Johnston, DH
中科院分区：
文献类型：
--
作者：
Barrett, EJ;Kenny, DJ;Johnston, DH
本研究的目的是确定将釉质基质蛋白衍生物Emdogain（R）（Biora AB马尔莫，瑞典）应用于撕脱的恒切牙的根表面是否会改善儿科人群的再植后结果。1999年6月至2002年5月，25个撕脱的上颌恒切牙（22个中切牙和3个中切牙）用Emdogain（R）治疗，随访32个月，平均20.6个月（范围：6.9-32.5个月）。治疗时患者平均年龄为12.0岁（范围：7.7-17.6岁），平均肺泡外持续时间为185分钟（范围：100-300分钟）。在他们的后续行动结束时，每一个再植的门牙表现出替代根吸收和临床证据的僵硬的放射学证据。没有一颗再植的牙齿受到炎症性牙根吸收的影响，也没有感染的证据。当与来自Barrett和Kenny的对照样品进行比较时（Endod Dent Trafficol 1997;15：269-72.）和Andersson等人（Endod Dent Trafficol 1989;5：38-47.）该用Emdogain方案处理的样品显示出比任一对照样品显著更少的牙根吸收（方差分析，P < 0.0001）。虽然Emdogain（R）方案没有产生牙周再生，但它确实消除了炎症性吸收和感染，并且与两个历史对照相比，导致牙根吸收显著减少。
The aim of this study was to determine whether application of an enamel matrix protein derivative, Emdogain(R) (Biora AB Malmo, Sweden) to the root surface of avulsed permanent incisors would improve postreplantation outcomes in a pediatric population. Between June 1999 and May 2002, 25 avulsed permanent maxillary incisors (22 centrals and three laterals) were treated with Emdogain(R) and followed for up to 32 months, mean duration 20.6 months (range: 6.9-32.5 months). Mean patient age at the time of treatment was 12.0 years (range: 7.7-17.6 years) and mean extra-alveolar duration was 185 min (range: 100-300 min). At the end of their follow-up each of the replanted incisors demonstrated radiographic evidence of replacement root resorption and clinical evidence of ankylosis. None of the replanted teeth were affected by inflammatory root resorption and there was no evidence of infection. When compared with the control samples from Barrett and Kenny (Endod Dent Traumatol 1997;15:269-72.) and Andersson et al. (Endod Dent Traumatol 1989;5:38-47.) this sample treated with the Emdogain(R) protocol demonstrated significantly less root resorption than either of the control samples (anova, P < 0.0001). Although the Emdogain(R) protocol did not produce periodontal regeneration, it did eliminate inflammatory resorption and infection and led to significantly less root resorption compared with the two historical controls.