HOW DOES THE ELECTRONEGATIVITY OF THE SUBSTITUENT DICTATE THE STRENGTH OF THE GAUCHE EFFECT
HOW DOES THE ELECTRONEGATIVITY OF THE SUBSTITUENT DICTATE THE STRENGTH OF THE GAUCHE EFFECT
复制标题
DOI：
10.1021/ja00088a043
复制
发表时间：
1994-05-04
影响因子：
15
通讯作者：
CHATTOPADHYAYA, J
中科院分区：
文献类型：
--
作者：
THIBAUDEAU, C;PLAVEC, J;CHATTOPADHYAYA, J
The distinct conformational preferences observed for the pentofuranosyl moieties in various 3'-substituted 2',3'-dideoxythymidine derivatives are closely related to the strength of the 3'-gauche effect, which is directly dictated by the electronegativity of the 3'-substituent. The efficiency of the 3'-gauche effect can now be quantitatively calculated with the help of simple linear calibration curves that correlate the gauche effect enthalpy (Delta H(GE)degrees and the group electronegativity (X) of the 3'-substituent.
