SEQUENCE-ANALYSIS OF PEPTIDES BOUND TO MHC CLASS-II MOLECULES
SEQUENCE-ANALYSIS OF PEPTIDES BOUND TO MHC CLASS-II MOLECULES
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DOI：
10.1038/353622a0
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发表时间：
1991-10-17
期刊：
影响因子：
64.8
通讯作者：
JANEWAY, CA
中科院分区：
文献类型：
--
作者：
RUDENSKY, AY;PRESTONHURLBURT, P;JANEWAY, CA
CD 4 T细胞识别与主要组织相容性复合体（MHC）的自身II类分子结合的外源蛋白的肽片段。与MHC II类分子结合的天然加工的肽片段是13-17个氨基酸的肽，其似乎是从羧基末端预先截短的，可能是在与MHC II类分子结合后。优势自身肽的发现对抗原加工和自我-非自我辨别具有重要意义。
CD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules of the major histocompatibility complex (MHC). Naturally processed peptide fragments bound to MHC class II molecules are peptides of 13-17 amino acids which appear to be precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II molecule. The finding of predominant self peptides has interesting implications for antigen processing and self-non-self discrimination.