ENTEROPATHOGENICITY OF AEROMONAS-HYDROPHILA AND PLESIOMONAS-SHIGELLOIDES - PREVALENCE AMONG INDIVIDUALS WITH AND WITHOUT DIARRHEA IN THAILAND
ENTEROPATHOGENICITY OF AEROMONAS-HYDROPHILA AND PLESIOMONAS-SHIGELLOIDES - PREVALENCE AMONG INDIVIDUALS WITH AND WITHOUT DIARRHEA IN THAILAND
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DOI：
10.1128/iai.35.2.666-673.1982
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
TINGTALAPONG, M
中科院分区：
文献类型：
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作者：
PITARANGSI, C;ECHEVERRIA, P;TINGTALAPONG, M
为了评价嗜水单胞杆菌和志贺氏杆菌的肠致病性，比较了泰国有腹泻和无腹泻人群中这两种细菌的分离率。在两组美国旅行者中，与没有腹泻的人相比，嗜水单胞杆菌与旅行者腹泻的发生率更高（P < 0.025），而志贺氏单胞杆菌与旅行者腹泻的发生率较低（P < 0.025）。在泰国3个种群中，从有腹泻和无腹泻个体中分离出的嗜水单胞杆菌和志贺氏单胞杆菌的频率相似。从有腹泻和无腹泻个体分离的嗜水单胞杆菌的生化特性、细胞毒素的产生和胀肠能力相似。然而，具有细胞毒性的嗜水单胞杆菌菌株会使家兔和哺乳小鼠肠道膨胀，并对两种动物的肠道粘膜产生破坏性损伤。志贺氏杆菌菌株既不产生细胞毒素，也不产生胀肠。口服具有细胞毒性的嗜水单胞杆菌或志贺氏单胞杆菌的全培养物（109）未能引起恒河猴腹泻。可能需要对腹泻患者进行自愿研究或肠道活检，以确定嗜水单胞杆菌是否是人类的胃肠道病原体。
To evaluate the enteropathogenicity of A. hydrophila and P. shigelloides, the rate of isolation of these organisms was compared among individuals with and without diarrhea in Thailand. In 2 groups of American travelers, A. hydrophila, but not P. shigelloides, was associated with episodes of travelers diarrhea more often than when individuals did not have diarrhea (P < 0.025). Among 3 populations of Thais, A. hydrophila and P. shigelloides were isolated with similar frequencies from individuals with and without diarrhea. The biochemical characteristics, production of cytotoxin and ability to distend suckling mouse intestine were similar among A. hydrophila isolates from individuals with and without diarrhea. However, cytotoxic A. hydrophila strains distended rabbit and suckling mouse intestine and produced destructive lesions in intestinal mucosa of both species of animal. P. shigelloides strains produced neither cytotoxin nor distended intestine. Oral administration of whole cultures (109) of cytotoxic A. hydrophila or P. shigelloides failed to cause diarrhea in rhesus monkeys. Volunteer studies or intestinal biopsies of patients with diarrhea may be required to establish whether A. hydrophila is a gastrointestinal pathogen in humans.